Literature DB >> 26856827

Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404.

Koen W R van Cleef1, Gijs J Overheul1, Michael C Thomassen1, Jenni M Marjakangas1, Ronald P van Rij2.   

Abstract

Despite the enormous disease burden associated with dengue virus infections, a licensed antiviral drug is lacking. Here, we show that the paracetamol (acetaminophen) metabolite AM404 inhibits dengue virus replication. Moreover, we find that mutations in NS4B that were previously found to confer resistance to the antiviral compounds NITD-618 and SDM25N also render dengue virus insensitive to AM404. Our work provides further support for NS4B as a direct or indirect target for antiviral drug development.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26856827      PMCID： PMC4808173          DOI： 10.1128/AAC.02462-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

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7.  Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis.

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  9 in total

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