Literature DB >> 25785167

Meta-analysis of methylenetetrahydrofolate reductase polymorphism and lung cancer risk in Chinese.

Xin Wang1, Kai Yue2, Liran Hao3.   

Abstract

Numerous studies have investigated association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with lung cancer (LC) susceptibility in Chinese; however, the findings are inconsistent. Therefore, we performed a meta-analysis. PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure, and Wanfang were searched. Pooled ORs and 95% CIs were used to assess the strength of the associations. Overall, 10 studies with 2487 cases and 3228 controls investigating the MTHFR C677T polymorphism and LC risk were included. We did not find a significant association between MTHFR C677T polymorphism and LC risk. However, significantly increased LC risk was found in the population from North China, which was not found in the population from South China. In conclusion, our meta-analysis suggested that MTHFR C677T polymorphism might influence the risk of LC.

Entities:  

Keywords:  Lung cancer; MTHFR; meta-analysis; polymorphism

Year:  2015        PMID： 25785167      PMCID： PMC4358622     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  15 in total

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Journal:  J Nutr Biochem       Date:  1999-02       Impact factor: 6.048

2.  The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.

Authors:  Anne Parle-McDermott; James L Mills; Anne M Molloy; Nicola Carroll; Peadar N Kirke; Christopher Cox; Mary R Conley; Faith J Pangilinan; Lawrence C Brody; John M Scott
Journal:  Mol Genet Metab       Date:  2006-04-18       Impact factor: 4.797

3.  Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.

Authors:  L L Stern; J B Mason; J Selhub; S W Choi
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2000-08       Impact factor: 4.254

4.  A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

Authors:  N M van der Put; F Gabreëls; E M Stevens; J A Smeitink; F J Trijbels; T K Eskes; L P van den Heuvel; H J Blom
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

Review 5.  Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis.

Authors:  Y I Kim
Journal:  Nutr Rev       Date:  2000-07       Impact factor: 7.110

6.  A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.

Authors:  P Frosst; H J Blom; R Milos; P Goyette; C A Sheppard; R G Matthews; G J Boers; M den Heijer; L A Kluijtmans; L P van den Heuvel
Journal:  Nat Genet       Date:  1995-05       Impact factor: 38.330

7.  Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.

Authors:  Takeshi Suzuki; Keitaro Matsuo; Akio Hiraki; Toshiko Saito; Shigeki Sato; Yasushi Yatabe; Tetsuya Mitsudomi; Toyoaki Hida; Ryuzo Ueda; Kazuo Tajima
Journal:  Carcinogenesis       Date:  2007-04-29       Impact factor: 4.944

8.  Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients.

Authors:  Chiu-Shong Liu; Chia-Wen Tsai; Te-Chun Hsia; Rou-Fen Wang; Chin-Jung Liu; Liang-Wen Hang; Su-Yin Chiang; Chung-Hsing Wang; Ru-Yin Tsai; Cheng-Chieh Lin; Da-Tian Bau
Journal:  Cancer Genomics Proteomics       Date:  2009 Nov-Dec       Impact factor: 4.069

9.  Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population.

Authors:  Hongliang Liu; Guangfu Jin; Haifeng Wang; Wenting Wu; Yanhong Liu; Ji Qian; Weiwei Fan; Hongxia Ma; Ruifen Miao; Zhibin Hu; Weiwei Sun; Yi Wang; Li Jin; Qingyi Wei; Hongbing Shen; Wei Huang; Daru Lu
Journal:  Lung Cancer       Date:  2008-01-24       Impact factor: 5.705

10.  The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.

Authors:  Yi-Lin Jeng; Mei-Hsuan Wu; Han-Bin Huang; Wei-Yu Lin; San-Lin You; Tang-Yuan Chu; Chien-Jen Chen; Chien-An Sun
Journal:  Anticancer Res       Date:  2003 Nov-Dec       Impact factor: 2.480
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  5 in total

1.  Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.

Authors:  Xin-Li Zhu; Zhi-Zhong Liu; Sen-Xiang Yan; Wei Wang; Rui-Xia Chang; Chun-Yan Zhang; Yan Guo
Journal:  Mol Genet Genomics       Date:  2015-07-09       Impact factor: 3.291

2.  Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.

Authors:  Shu-Zhe Xie; Zhi-Zhong Liu; Jun-hua Yu; Li Liu; Wei Wang; Dao-Lin Xie; Jiang-Bo Qin
Journal:  Tumour Biol       Date:  2015-06-17

3.  Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of non-small cell lung cancer in eastern Chinese Han population.

Authors:  Hao Ding; Yafeng Wang; Yuanmei Chen; Chao Liu; Hao Qiu; Mingqiang Kang; Weifeng Tang
Journal:  Oncotarget       Date:  2017-12-04

4.  Individual and combined effect of TP53, MDM2, MDM4, MTHFR, CCR5, and CASP8 gene polymorphisms in lung cancer.

Authors:  Ausra Stumbryte; Zivile Gudleviciene; Gabrielis Kundrotas; Daiva Dabkeviciene; Agne Kunickaite; Saulius Cicenas
Journal:  Oncotarget       Date:  2017-11-29

5.  Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people: An updated meta-analysis.

Authors:  Rui Zhong; Qingling Chen; Xinyue Zhang; Mengmeng Li; Xin Zhang; Weihong Lin
Journal:  Medicine (Baltimore)       Date:  2019-06       Impact factor: 1.817
  5 in total

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