BACKGROUND: We examined the relationship of the MTHFR C677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan. MATERIALS AND METHODS: A total of 59 histologically confirmed lung cancer cases and 232 cancer-free controls were recruited between July 1990 and December 2000. The MTHFR C677T genotype was determined by a PCR-restriction fragment length polymorphism assay. RESULTS: The MTHFR 677T variant genotype, including 677CT and 677TT, was observed in 39% of cases and 47% of controls. The resultant adjusted odds ratio (OR) was 0.71 (95% confidence interval [CI] = 0.39-1.30). The inverse association of the MTHFR 677T variant genotype with lung cancer risk was apparent in both smokers and nonsmokers. CONCLUSION: These results suggest that the MTHFR 677T variant genotype reduces the risk of lung cancer. Larger studies incorporating dietary folate intake and the variant genotypes are needed to clarify our results.
BACKGROUND: We examined the relationship of the MTHFRC677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan. MATERIALS AND METHODS: A total of 59 histologically confirmed lung cancer cases and 232 cancer-free controls were recruited between July 1990 and December 2000. The MTHFRC677T genotype was determined by a PCR-restriction fragment length polymorphism assay. RESULTS: The MTHFR 677T variant genotype, including 677CT and 677TT, was observed in 39% of cases and 47% of controls. The resultant adjusted odds ratio (OR) was 0.71 (95% confidence interval [CI] = 0.39-1.30). The inverse association of the MTHFR 677T variant genotype with lung cancer risk was apparent in both smokers and nonsmokers. CONCLUSION: These results suggest that the MTHFR 677T variant genotype reduces the risk of lung cancer. Larger studies incorporating dietary folate intake and the variant genotypes are needed to clarify our results.
Authors: E Vairaktaris; C Yapijakis; P Kessler; A Vylliotis; J Ries; J Wiltfang; S Vassiliou; S Derka; F W Neukam Journal: J Cancer Res Clin Oncol Date: 2005-12-20 Impact factor: 4.553
Authors: Therese Truong; Wiebke Sauter; James D McKay; H Dean Hosgood; Carla Gallagher; Christopher I Amos; Margaret Spitz; Joshua Muscat; Philip Lazarus; Thomas Illig; H Erich Wichmann; Heike Bickeböller; Angela Risch; Hendrik Dienemann; Zuo-Feng Zhang; Behnaz Pezeshki Naeim; Ping Yang; Shanbeh Zienolddiny; Aage Haugen; Loïc Le Marchand; Yun-Chul Hong; Jin Hee Kim; Eric J Duell; Angeline S Andrew; Chikako Kiyohara; Hongbing Shen; Keitaro Matsuo; Takeshi Suzuki; Adeline Seow; Daniel P K Ng; Qing Lan; David Zaridze; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Vali Constantinescu; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Neil E Caporaso; Demetrius Albanes; Michael Thun; Maria Teresa Landi; Joanna Trubicka; Marcin Lener; Jan Lubinski; Ying Wang; Amélie Chabrier; Paolo Boffetta; Paul Brennan; Rayjean J Hung Journal: Carcinogenesis Date: 2010-01-27 Impact factor: 4.944
Authors: Yao Zhang; Guo Qiang Chen; Yong Ji; Bin Huang; Wei Sheng Shen; Li Chun Deng; Lei Xi; Xiang Ming Cao Journal: Mol Biol Rep Date: 2012-01-04 Impact factor: 2.316