| Literature DB >> 16621645 |
Anne Parle-McDermott1, James L Mills, Anne M Molloy, Nicola Carroll, Peadar N Kirke, Christopher Cox, Mary R Conley, Faith J Pangilinan, Lawrence C Brody, John M Scott.
Abstract
Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A>C, is associated with increased RCF levels. Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms.Entities:
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Year: 2006 PMID： 16621645 DOI： 10.1016/j.ymgme.2006.02.011
Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797