| Literature DB >> 25782743 |
Matthew J Weaver1, Alison K Kearns1, Sascha Stump1, Chun Li2, Mariusz P Gajewski3, Kevin C Rider1, Donald S Backos4, Philip R Reigan5, Howard D Beall6, Nicholas R Natale7.
Abstract
Using the structure-activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hypothesis. Finally, we show that AIMs induce apoptosis in SNB-19 cells.Entities:
Keywords: Anthracene; DNA Quadruplex; Glioblastoma; Isoxazole; Pyrrole; Tumor paint
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Year: 2015 PMID： 25782743 PMCID： PMC4599781 DOI： 10.1016/j.bmcl.2015.02.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823