| Literature DB >> 11263885 |
C C Smeltzer1, M J Cannon, P R Pinson, J D Munger, F G West, C B Grissom.
Abstract
Fluorescent derivatives of cobalamin have been prepared by linking fluorophores to cobalamin through a propylamide spacer. Fluorescein, naphthofluorescein, and Oregon Green derivatives have been prepared in good yield by reaction of the fluorophore NHS-ester with beta-(3-aminopropyl)cobalamin to form fluorescent cobalamin conjugates (CobalaFluors) that are potentially suitable for the in vitro and in vivo imaging of transcobalamin receptors on cancer cells.Entities:
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Year: 2001 PMID： 11263885 DOI： 10.1021/ol006825v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005