Masaya Suda1,2, Masahisa Onoguchi3, Takeshi Tomiyama4, Keiichi Ishihara5, Naoto Takahashi6, Minoru Sakurai5, Keiichi Matsumoto7, Shin-Ichiro Kumita4. 1. Department of Quantum Medical Technology, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Ishikawa, Japan. msuda@nms.ac.jp. 2. Clinical Imaging Center for Healthcare, Nippon Medical School, Tokyo, Japan. msuda@nms.ac.jp. 3. Department of Quantum Medical Technology, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Ishikawa, Japan. onoguchi@staff.kanazawa-u.ac.jp. 4. Department of Radiology, Nippon Medical School, Tokyo, Japan. 5. Clinical Imaging Center for Healthcare, Nippon Medical School, Tokyo, Japan. 6. Department of Cardiology, Nippon Medical School, Tokyo, Japan. 7. Kyoto College of Medical Science, Nantan, Japan.
Abstract
BACKGROUND: This study aimed to validate the reproducibility of quantitative analysis using time-of-flight (TOF) and conventional PET with (13)N-ammonia ((13)N-NH3). METHODS AND RESULTS: Phantom images were reconstructed with and without TOF, and recovery coefficients (RCs) and the percent contrast of each sphere over the percent background variability were assessed. In the clinical study, 21 subjects underwent dynamic (13)N-NH3 PET scanning under stress and rest conditions. The dynamic acquisition images and intra- and inter-observer reproducibility of myocardial blood flow (MBF) and coronary flow reserve (CFR) were compared between reconstructions (with and without TOF). In the phantom study, RCs and the percent contrast of each sphere over the percent background variability was improved with TOF. In the clinical study, the noise of blood pool and myocardial images with TOF was less than that without TOF. Territorial and global intra- and inter-observer reproducibility of MBF and CFR values was excellent. Although segmental intra- and inter-observer reproducibility was excellent, there were larger variations in apex and the segment near the right ventricle (RV) without TOF. These variations became inconspicuous with TOF. CONCLUSION: Visual image quality, RCs, and percent contrast over percent background variability with TOF were better than that without TOF. Excellent correlations and good agreements in quantitative values were observed. TOF improved the variation of segmental values.
BACKGROUND: This study aimed to validate the reproducibility of quantitative analysis using time-of-flight (TOF) and conventional PET with (13)N-ammonia ((13)N-NH3). METHODS AND RESULTS: Phantom images were reconstructed with and without TOF, and recovery coefficients (RCs) and the percent contrast of each sphere over the percent background variability were assessed. In the clinical study, 21 subjects underwent dynamic (13)N-NH3 PET scanning under stress and rest conditions. The dynamic acquisition images and intra- and inter-observer reproducibility of myocardial blood flow (MBF) and coronary flow reserve (CFR) were compared between reconstructions (with and without TOF). In the phantom study, RCs and the percent contrast of each sphere over the percent background variability was improved with TOF. In the clinical study, the noise of blood pool and myocardial images with TOF was less than that without TOF. Territorial and global intra- and inter-observer reproducibility of MBF and CFR values was excellent. Although segmental intra- and inter-observer reproducibility was excellent, there were larger variations in apex and the segment near the right ventricle (RV) without TOF. These variations became inconspicuous with TOF. CONCLUSION: Visual image quality, RCs, and percent contrast over percent background variability with TOF were better than that without TOF. Excellent correlations and good agreements in quantitative values were observed. TOF improved the variation of segmental values.
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