| Literature DB >> 25770841 |
Christos A Goudis1, Panagiotis Korantzopoulos2, Ioannis V Ntalas3, Eleftherios M Kallergis4, Tong Liu5, Dimitrios G Ketikoglou6.
Abstract
Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, including oxidative stress, connexin remodeling and glycemic fluctuations seem to be implicated in AF pathophysiology in the setting of DM. The present review highlights the association between DM and AF, provides a comprehensive overview of the responsible pathophysiological mechanisms and briefly discusses potential upstream therapies for DM-related atrial remodeling.Entities:
Keywords: Atrial fibrillation; Atrial remodeling; Diabetes mellitus; Upstream therapies
Mesh:
Substances:
Year: 2015 PMID: 25770841 DOI: 10.1016/j.ijcard.2015.03.052
Source DB: PubMed Journal: Int J Cardiol ISSN: 0167-5273 Impact factor: 4.164