Literature DB >> 25758540

A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines.

Remani Vasudevan Sumesh1, Akilan Malathi, Raju Ranjith Kumar.   

Abstract

A facile and efficient synthesis of a library of novel chromeno[3,2-c]pyridines has been achieved from the reaction of various 3,5-((E)-arylidene)-1-alkylpiperidin-4-ones and cyclic 1,3-diketones. The reaction presumably occurred via tandem Michael addition-intramolecular O-cyclization-elimination sequence in a single operation.

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Year:  2015        PMID： 25758540     DOI： 10.1007/s11030-015-9576-4

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  26 in total

1.  Domino Reactions in Organic Synthesis.

Authors:  Lutz F. Tietze
Journal:  Chem Rev       Date:  1996-02-01       Impact factor: 60.622

2.  Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.

Authors:  P C Unangst; T Capiris; D T Connor; T G Heffner; R G MacKenzie; S R Miller; T A Pugsley; L D Wise
Journal:  J Med Chem       Date:  1997-08-15       Impact factor: 7.446

3.  Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

Authors:  David R Anderson; Shridhar Hegde; Emily Reinhard; Leslie Gomez; William F Vernier; Len Lee; Shuang Liu; Aruna Sambandam; Patricia A Snider; Liaqat Masih
Journal:  Bioorg Med Chem Lett       Date:  2005-03-15       Impact factor: 2.823

Review 4.  Cascade reactions in total synthesis.

Authors:  K C Nicolaou; David J Edmonds; Paul G Bulger
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-06       Impact factor: 15.336

5.  Four-component domino strategy for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines.

Authors:  Selvaraj Kanchithalaivan; Sathiyamoorthi Sivakumar; Raju Ranjith Kumar; Palani Elumalai; Qazi Naveed Ahmed; Anil K Padala
Journal:  ACS Comb Sci       Date:  2013-10-30       Impact factor: 3.784

6.  Discovery of novel antitubercular 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives.

Authors:  Dharmarajan Sriram; Perumal Yogeeswari; Murugesan Dinakaran; Debjani Banerjee; Pritesh Bhat; Sunil Gadhwal
Journal:  Eur J Med Chem       Date:  2009-09-20       Impact factor: 6.514

7.  Synthesis of quinolines from 3-formylchromone.

Authors:  Andrey S Plaskon; Sergey V Ryabukhin; Dmitriy M Volochnyuk; Konstantin S Gavrilenko; Alexander N Shivanyuk; Andrey A Tolmachev
Journal:  J Org Chem       Date:  2008-07-02       Impact factor: 4.354

8.  All-carbon quaternary stereogenic centers in acyclic systems through the creation of several C-C bonds per chemical step.

Authors:  Ilan Marek; Yury Minko; Morgane Pasco; Tom Mejuch; Noga Gilboa; Helena Chechik; Jaya P Das
Journal:  J Am Chem Soc       Date:  2014-02-10       Impact factor: 15.419

9.  Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention.

Authors:  Raju Ranjith Kumar; Subbu Perumal; Palaniappan Senthilkumar; Perumal Yogeeswari; Dharmarajan Sriram
Journal:  J Med Chem       Date:  2008-08-21       Impact factor: 7.446

10.  Domino reaction of arylglyoxals with pyrazol-5-amines: selective access to pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles.

Authors:  Bo Jiang; Wei Fan; Mu-Yan Sun; Qin Ye; Shu-Liang Wang; Shu-Jiang Tu; Guigen Li
Journal:  J Org Chem       Date:  2014-05-22       Impact factor: 4.354
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