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Literature DB >> 15745802

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

David R Anderson¹, Shridhar Hegde, Emily Reinhard, Leslie Gomez, William F Vernier, Len Lee, Shuang Liu, Aruna Sambandam, Patricia A Snider, Liaqat Masih.

Abstract

A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFalpha in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported.

Entities: Chemical Gene

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Year: 2005 PMID： 15745802 DOI： 10.1016/j.bmcl.2005.01.067

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

26 in total

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2. The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.

Authors: Adam D Bachstetter; Linda J Van Eldik
Journal: Aging Dis Date: 2010-09-24 Impact factor: 6.745

3. Role of MK2 signaling pathway in the chronic compression of cervical spinal cord.

Authors: Hongxing Song; Xiutong Fang; Mingjie Wen; Fang Yu; Kai Gao; Chenli Sun; Zhenwei Wang
Journal: Am J Transl Res Date: 2015-11-15 Impact factor: 4.060

Review 4. Targeting innate immunity protein kinase signalling in inflammation.

Authors: Matthias Gaestel; Alexey Kotlyarov; Michael Kracht
Journal: Nat Rev Drug Discov Date: 2009-06 Impact factor: 84.694

5. Application of nitrogen-rich porous organic polymer for the solid-phase synthesis of 2-amino-4H-benzo[b]pyran scaffolds using ball milling process.

Authors: Lia Zaharani; Nader Ghaffari Khaligh; Taraneh Mihankhah; Mohd Rafie Johan
Journal: Mol Divers Date: 2020-05-02 Impact factor: 2.943

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

1. An efficient, multicomponent approach for solvent-free synthesis of 2-amino-4H-chromene scaffold.

2. The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.

3. Role of MK2 signaling pathway in the chronic compression of cervical spinal cord.

Review 4. Targeting innate immunity protein kinase signalling in inflammation.

5. Application of nitrogen-rich porous organic polymer for the solid-phase synthesis of 2-amino-4H-benzo[b]pyran scaffolds using ball milling process.

6. Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.

7. A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines.

8. The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response.

9. Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.

10. A new one-pot three-component synthesis of 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitrile derivatives.