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Literature DB >> 17075967

Cascade reactions in total synthesis.

K C Nicolaou¹, David J Edmonds, Paul G Bulger.

Abstract

The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

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Year: 2006 PMID： 17075967 DOI： 10.1002/anie.200601872

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

141 in total

1. REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES.

Authors: Jin-Peng Zhang; Wei Fan; Jie Ding; Bo Jiang; Shu-Jiang Tu; Guigen Li
Journal: Heterocycles Date: 2013-12-17 Impact factor: 0.831

2. Enantioselective synthesis of bicylco[3.2.1]octan-8-ones using a tandem Michael-Henry reaction.

Authors: Derong Ding; Cong-Gui Zhao; Qunsheng Guo; Hadi Arman
Journal: Tetrahedron Date: 2010-06-19 Impact factor: 2.457

Review 3. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors: K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal: Chem Soc Rev Date: 2012-06-28 Impact factor: 54.564

9. Origin of stereocontrol in the construction of the 12-oxatricyclo[6.3.1.0(2,7)]dodecane ring system by Prins-pinacol reactions.

Authors: Larry E Overman; Paul S Tanis
Journal: J Org Chem Date: 2010-01-15 Impact factor: 4.354

10. Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.

Authors: K C Nicolaou; Jochen Becker; Yee Hwee Lim; Alexandre Lemire; Thomas Neubauer; Ana Montero
Journal: J Am Chem Soc Date: 2009-10-21 Impact factor: 15.419

Cascade reactions in total synthesis.

1. REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES.

2. Enantioselective synthesis of bicylco[3.2.1]octan-8-ones using a tandem Michael-Henry reaction.

Review 3. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Review 4. Organocatalytic cascade reactions as a new tool in total synthesis.

5. Spatially orthogonal chemical functionalization of a hierarchical pore network for catalytic cascade reactions.

6. Iminium Ion Cascade Reactions: Stereoselective Synthesis of Quinolizidines and Indolizidines.

7. Catalytic Radical Domino Reactions in Organic Synthesis.

8. Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.

9. Origin of stereocontrol in the construction of the 12-oxatricyclo[6.3.1.0(2,7)]dodecane ring system by Prins-pinacol reactions.

10. Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.