Literature DB >> 2575609

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer.

T Tsuchiya1, Y Ueyama, N Tamaoki, S Yamaguchi, M Shibuya.   

Abstract

c-erbB-2 oncogene has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co-amplified c-myc and c-erbB-2 oncogenes: a portion of the amplified c-erbB-2 oncogene was found to be rearranged. Furthermore, c-myc and c-erbB-2 oncogenes were over-expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tumorigenic in nude mice. These results might suggest that activated c-myc and c-erbB-2 oncogenes co-operate and influence the malignant state of some gastric carcinomas.

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Year:  1989        PMID： 2575609      PMCID： PMC5917887          DOI： 10.1111/j.1349-7006.1989.tb01626.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  21 in total

1.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.

Authors:  H Nakatani; E Tahara; T Yoshida; H Sakamoto; T Suzuki; H Watanabe; M Sekiguchi; Y Kaneko; M Sakurai; M Terada
Journal:  Jpn J Cancer Res       Date:  1986-09

2.  Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells.

Authors:  M Shibuya; J Yokota; Y Ueyama
Journal:  Mol Cell Biol       Date:  1985-02       Impact factor: 4.272

3.  Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Authors:  K Alitalo; M Schwab; C C Lin; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

4.  Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient.

Authors:  R Dalla-Favera; F Wong-Staal; R C Gallo
Journal:  Nature       Date:  1982-09-02       Impact factor: 49.962

5.  Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.

Authors:  T Yamamoto; S Ikawa; T Akiyama; K Semba; N Nomura; N Miyajima; T Saito; K Toyoshima
Journal:  Nature       Date:  1986 Jan 16-22       Impact factor: 49.962

6.  Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

Authors:  J Yokota; T Yamamoto; N Miyajima; K Toyoshima; N Nomura; H Sakamoto; T Yoshida; M Terada; T Sugimura
Journal:  Oncogene       Date:  1988-03       Impact factor: 9.867

7.  Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Authors:  R Taub; I Kirsch; C Morton; G Lenoir; D Swan; S Tronick; S Aaronson; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

8.  Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

Authors:  H Yamazaki; Y Fukui; Y Ueyama; N Tamaoki; T Kawamoto; S Taniguchi; M Shibuya
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272

9.  A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

Authors:  Y Taya; K Hosogai; S Hirohashi; Y Shimosato; R Tsuchiya; N Tsuchida; M Fushimi; T Sekiya; S Nishimura
Journal:  EMBO J       Date:  1984-12-01       Impact factor: 11.598

10.  Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma.

Authors:  S Ikeda; H Sumii; K Akiyama; S Watanabe; S Ito; H Inoue; H Takechi; G Tanabe; T Oda
Journal:  Jpn J Cancer Res       Date:  1989-01
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