Literature DB >> 2579323

Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells.

M Shibuya, J Yokota, Y Ueyama.   

Abstract

Three of 16 human gastric adenocarcinoma samples, maintained as solid tumors in nude mice, were found to carry amplified c-myc genes. In two samples with a high degree of c-myc DNA amplification (15- to 30-fold), double minute chromosomes were observed in karyotype analysis. The level of c-myc RNA was markedly elevated in a rapidly growing and poorly differentiated tumor, whereas it was only slightly elevated in a slowly growing and more differentiated tumor.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2579323      PMCID： PMC366726          DOI： 10.1128/mcb.5.2.414-418.1985

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  33 in total

1.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

2.  Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Authors:  K Alitalo; M Schwab; C C Lin; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

3.  Two human c-onc genes are located on the long arm of chromosome 8.

Authors:  B G Neel; S C Jhanwar; R S Chaganti; W S Hayward
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

Review 4.  Double minutes and homogeneously staining regions: gene amplification in mammalian cells.

Authors:  J K Cowell
Journal:  Annu Rev Genet       Date:  1982       Impact factor: 16.830

5.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

Authors:  E P Reddy; R K Reynolds; E Santos; M Barbacid
Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

6.  Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29.

Authors:  W W Colby; E Y Chen; D H Smith; A D Levinson
Journal:  Nature       Date:  1983-02-24       Impact factor: 49.962

7.  Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

Authors:  P C Brown; S M Beverley; R T Schimke
Journal:  Mol Cell Biol       Date:  1981-12       Impact factor: 4.272

8.  Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Authors:  R Dalla-Favera; M Bregni; J Erikson; D Patterson; R C Gallo; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

9.  Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Authors:  R Taub; I Kirsch; C Morton; G Lenoir; D Swan; S Tronick; S Aaronson; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.

Authors:  M Schwab; K Alitalo; H E Varmus; J M Bishop; D George
Journal:  Nature       Date:  1983 Jun 9-15       Impact factor: 49.962
View more
  16 in total

Review 1.  Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.

Authors:  Justin M Drake; John K Lee; Owen N Witte
Journal:  Mol Cell Biol       Date:  2014-02-24       Impact factor: 4.272

2.  Nucleotide sequence of HBI, a novel recombinant MC29 derivative with altered pathogenic properties.

Authors:  D R Smith; B Vennstrom; M J Hayman; P J Enrietto
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

Review 3.  Human cancer and cellular oncogenes.

Authors:  S Nishimura; T Sekiya
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

4.  Neoplastic transformation of rat 3Y1 cells by a transcriptionally activated human c-myc gene and stabilization of p53 cellular tumor antigen in the transformed cells.

Authors:  K Shiroki; K Segawa; Y Koita; M Shibuya
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272

5.  Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.

Authors:  R Gonsky; J A Knauf; R Elisei; J W Wang; S Su; J A Fagin
Journal:  Nucleic Acids Res       Date:  1997-10-01       Impact factor: 16.971

6.  Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers.

Authors:  A Terano; R Nakada; H Mutoh; H Hiraishi; S Ota; S Shiina; T Shimada; Y Itoh; K Kimura; J Shiga
Journal:  Gastroenterol Jpn       Date:  1991-02

7.  Androgen regulation of a specific gene in hamster flank organs.

Authors:  H Hisaoka; R Ideta; T Seki; K Adachi
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

8.  Growth regulation of rabbit gastric epithelial cells and protooncogene expression.

Authors:  K Yoshiura; S Ota; A Terano; M Takahashi; Y Hata; T Kawabe; H Mutoh; H Hiraishi; R Nakata; K Okano
Journal:  Dig Dis Sci       Date:  1994-07       Impact factor: 3.199

9.  K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

Authors:  Y Hattori; H Odagiri; H Nakatani; K Miyagawa; K Naito; H Sakamoto; O Katoh; T Yoshida; T Sugimura; M Terada
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

10.  Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

Authors:  H Yamazaki; Y Fukui; Y Ueyama; N Tamaoki; T Kawamoto; S Taniguchi; M Shibuya
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.