Literature DB >> 25753149

Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic.

Eric M Lewandowski1, Joanna Skiba, Nicholas J Torelli, Aleksandra Rajnisz, Jolanta Solecka, Konrad Kowalski, Yu Chen.   

Abstract

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

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Year:  2015        PMID： 25753149      PMCID： PMC4374039          DOI： 10.1039/c5cc00904a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  30 in total

1.  Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.

Authors:  Adam J Salmon; Michael L Williams; Andreas Hofmann; Sally-Ann Poulsen
Journal:  Chem Commun (Camb)       Date:  2012-01-18       Impact factor: 6.222

Review 2.  Small organometallic compounds as antibacterial agents.

Authors:  Malay Patra; Gilles Gasser; Nils Metzler-Nolte
Journal:  Dalton Trans       Date:  2012-03-12       Impact factor: 4.390

3.  Structural insights into substrate recognition and product expulsion in CTX-M enzymes.

Authors:  Julien Delmas; David Leyssene; Damien Dubois; Catherine Birck; Emilie Vazeille; Frédéric Robin; Richard Bonnet
Journal:  J Mol Biol       Date:  2010-05-07       Impact factor: 5.469

4.  The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution.

Authors:  Yu Chen; Richard Bonnet; Brian K Shoichet
Journal:  J Am Chem Soc       Date:  2007-04-05       Impact factor: 15.419

Review 5.  Resistance to antibiotics targeted to the bacterial cell wall.

Authors:  I Nikolaidis; S Favini-Stabile; A Dessen
Journal:  Protein Sci       Date:  2014-01-17       Impact factor: 6.725

Review 6.  Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria.

Authors:  Karen Bush; Jed F Fisher
Journal:  Annu Rev Microbiol       Date:  2011       Impact factor: 15.500

7.  Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.

Authors:  Christoph Reiter; Aysun Capcı Karagöz; Tony Fröhlich; Volker Klein; Maen Zeino; Katrin Viertel; Jana Held; Benjamin Mordmüller; Safiye Emirdağ Öztürk; Hüseyin Anıl; Thomas Efferth; Svetlana B Tsogoeva
Journal:  Eur J Med Chem       Date:  2014-01-31       Impact factor: 6.514

Review 8.  The future of the β-lactams.

Authors:  Leticia I Llarrull; Sebastian A Testero; Jed F Fisher; Shahriar Mobashery
Journal:  Curr Opin Microbiol       Date:  2010-09-29       Impact factor: 7.934

9.  Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics.

Authors:  Michaela Wenzel; Malay Patra; Christoph Helmut Rudi Senges; Ingo Ott; Jennifer Janina Stepanek; Antonio Pinto; Pascal Prochnow; Cuong Vuong; Sina Langklotz; Nils Metzler-Nolte; Julia Elisabeth Bandow
Journal:  ACS Chem Biol       Date:  2013-04-26       Impact factor: 5.100

Review 10.  Organometallic anticancer compounds.

Authors:  Gilles Gasser; Ingo Ott; Nils Metzler-Nolte
Journal:  J Med Chem       Date:  2010-11-15       Impact factor: 7.446
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  7 in total

1.  Influence of substrates and inhibitors on the structure of Klebsiella pneumoniae carbapenemase-2.

Authors:  Ben A Shurina; Richard C Page
Journal:  Exp Biol Med (Maywood)       Date:  2019-06-04

2.  Mechanisms of proton relay and product release by Class A β-lactamase at ultrahigh resolution.

Authors:  Eric M Lewandowski; Kathryn G Lethbridge; Ruslan Sanishvili; Joanna Skiba; Konrad Kowalski; Yu Chen
Journal:  FEBS J       Date:  2017-11-20       Impact factor: 5.542

3.  Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).

Authors:  Orville A Pemberton; Xiujun Zhang; Yu Chen
Journal:  J Med Chem       Date:  2017-04-17       Impact factor: 7.446

4.  Antibacterial Properties of Metallocenyl-7-ADCA Derivatives and Structure in Complex with CTX-M β-Lactamase.

Authors:  Eric M Lewandowski; Łukasz Szczupak; Stephanie Wong; Joanna Skiba; Adam Guśpiel; Jolanta Solecka; Valerije Vrček; Konrad Kowalski; Yu Chen
Journal:  Organometallics       Date:  2017-02-01       Impact factor: 3.876

Review 5.  Rational approaches towards inorganic and organometallic antibacterials.

Authors:  Jeannine Hess
Journal:  Biol Chem       Date:  2021-07-13       Impact factor: 4.700

6.  Erythromycin Modification That Improves Its Acidic Stability while Optimizing It for Local Drug Delivery.

Authors:  Erika L Cyphert; Jaqueline D Wallat; Jonathan K Pokorski; Horst A von Recum
Journal:  Antibiotics (Basel)       Date:  2017-04-25

7.  Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

Authors:  Nichola A Smith; Pingyu Zhang; Simon E Greenough; Michael D Horbury; Guy J Clarkson; Daniel McFeely; Abraha Habtemariam; Luca Salassa; Vasilios G Stavros; Christopher G Dowson; Peter J Sadler
Journal:  Chem Sci       Date:  2016-08-30       Impact factor: 9.825
  7 in total

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