Iris Friedli1, Lindsey A Crowe2, Magalie Viallon2, David A Porter3, Pierre-Yves Martin4, Sophie de Seigneux4, Jean-Paul Vallée5. 1. Division of Radiology, Department of Radiology and Medical Informatics, Geneva University Hospitals and Faculty of Medicine of the University of Geneva, Switzerland. Electronic address: Iris.Friedli@unige.ch. 2. Division of Radiology, Department of Radiology and Medical Informatics, Geneva University Hospitals and Faculty of Medicine of the University of Geneva, Switzerland. 3. Siemens AG, Healthcare Sector, Erlangen, Germany. 4. Division of Nephrology, Geneva University Hospitals and Faculty of Medicine of the University of Geneva, Switzerland. 5. Division of Radiology, Department of Radiology and Medical Informatics, Geneva University Hospitals and Faculty of Medicine of the University of Geneva, Switzerland. Electronic address: Jean-Paul.Vallee@hcuge.ch.
Abstract
PURPOSE: To assess the feasibility of a respiratory-gated implementation of readout-segmented SE-EPI (RESOLVE) for renal diffusion-weighted imaging (DWI) by comparison with single-shot SE-EPI (ss-EPI) in a phantom, healthy volunteers and chronic kidney disease (CKD) patients. MATERIALS AND METHODS: A fluid-filled phantom, 20 healthy volunteers and 10 CKD patients were scanned with the same parameters and coils on a 3T MR system with 3 DW sequences (b-values=0, 300, 500, 900s/mm(2)): a standard ss-EPI (Reference EPI), a ss-EPI with higher resolution, bandwidth and acceleration factor (HR-EPI) and RESOLVE with the same spatial resolution as HR-EPI but a segmentation of the readout into 5 shots. Geometric distortions, image blurring using a 'Canny' edge detection based measure, cortico-medullary differentiation measured on b0 images and ADC quantification were compared between the 3 sequences using one-way analysis of variance (ANOVA) with post-hoc Bonferroni (p<0.05 was taken as statistically significant). RESULTS: RESOLVE reduced significantly geometric distortions and blurring and improved, in the volunteers and patients, the sharpness score by 56% on average in comparison to ss-EPI (p=0.02). In healthy volunteers, the cortico-medullary differentiation with RESOLVE was also possible on a wider range of b-values (p<0.02) with ADC values (in 10(-6)mm(2)/s) of 1994±246 in the cortex and 1762±238 in the medulla (p<0.001). In CKD patients, ADC values (in 10(-6)mm(2)/s) from the RESOLVE sequence were not different between the cortex (1755±145) and the medulla (1799±163, p=0.49). CONCLUSION: Despite a longer scan time, RESOLVE enhanced significantly the quality of renal diffusion-weighted images by improving the difference in SI and ADC between the renal cortex and medulla in healthy volunteers. In CKD patients, RESOLVE showed a disappearance of this cortico-medullary ADC difference. These improvements justify further clinical studies.
PURPOSE: To assess the feasibility of a respiratory-gated implementation of readout-segmented SE-EPI (RESOLVE) for renal diffusion-weighted imaging (DWI) by comparison with single-shot SE-EPI (ss-EPI) in a phantom, healthy volunteers and chronic kidney disease (CKD) patients. MATERIALS AND METHODS: A fluid-filled phantom, 20 healthy volunteers and 10 CKDpatients were scanned with the same parameters and coils on a 3T MR system with 3 DW sequences (b-values=0, 300, 500, 900s/mm(2)): a standard ss-EPI (Reference EPI), a ss-EPI with higher resolution, bandwidth and acceleration factor (HR-EPI) and RESOLVE with the same spatial resolution as HR-EPI but a segmentation of the readout into 5 shots. Geometric distortions, image blurring using a 'Canny' edge detection based measure, cortico-medullary differentiation measured on b0 images and ADC quantification were compared between the 3 sequences using one-way analysis of variance (ANOVA) with post-hoc Bonferroni (p<0.05 was taken as statistically significant). RESULTS: RESOLVE reduced significantly geometric distortions and blurring and improved, in the volunteers and patients, the sharpness score by 56% on average in comparison to ss-EPI (p=0.02). In healthy volunteers, the cortico-medullary differentiation with RESOLVE was also possible on a wider range of b-values (p<0.02) with ADC values (in 10(-6)mm(2)/s) of 1994±246 in the cortex and 1762±238 in the medulla (p<0.001). In CKDpatients, ADC values (in 10(-6)mm(2)/s) from the RESOLVE sequence were not different between the cortex (1755±145) and the medulla (1799±163, p=0.49). CONCLUSION: Despite a longer scan time, RESOLVE enhanced significantly the quality of renal diffusion-weighted images by improving the difference in SI and ADC between the renal cortex and medulla in healthy volunteers. In CKDpatients, RESOLVE showed a disappearance of this cortico-medullary ADC difference. These improvements justify further clinical studies.
Authors: I Friedli; L A Crowe; L Berchtold; S Moll; K Hadaya; T de Perrot; C Vesin; P-Y Martin; S de Seigneux; J-P Vallée Journal: Sci Rep Date: 2016-07-21 Impact factor: 4.379
Authors: Peigang Ning; Dapeng Shi; Geoffrey A Sonn; Shreyas S Vasanawala; Andreas M Loening; Pejman Ghanouni; Piotr Obara; Lewis K Shin; Richard E Fan; Brian A Hargreaves; Bruce L Daniel Journal: Sci Rep Date: 2018-02-21 Impact factor: 4.379