G Pabst1, A-K Zimmermann, C Huth, W Koenig, T Ludwig, A Zierer, A Peters, B Thorand. 1. Barbara Thorand, Helmholtz Zentrum München, GmbH, Institute of Epidemiology II, Ingolstädter Landstraβe 1, D-85764 Neuherberg, Phone: +49-(0)89-3187-4480, Fax: +49-(0)89-3187-3667, E-Mail: thorand@helmholtz-muenchen.de.
Abstract
OBJECTIVES: Older adults often suffer from vitamin D deficiency and from the frailty syndrome charac-terized by different physical limitations, complicating independent everyday life. Previous studies have suggested a relationship between vitamin D status and the frailty syndrome, but results have been partly inconsistent, particularly regarding the shape of the association. Therefore, our aim was to further assess the association of 25-hydroxyvitamin D (25(OH)D) serum levels and frailty in older participants. DESIGN: Cross-sectional population-based study. PARTICIPANTS: The study population included 478 men and 462 women of the KORA (COoperative health research in the Region of Augsburg)-Age study born before 1944 examined in 2009. MEASUREMENTS: Classification of participants into different frailty states was performed according to the following criteria: weight loss, exhaustion, physical inactivity, slowness, and weakness. PARTICIPANTS who met 1-2 or ≥ 3 of the 5 criteria were classified as prefrail or frail, respectively. Total 25(OH)D was measured in non-fasting serum samples with an enhanced chemiluminescence immunoassay. Sequential logistic regression models adjusted for age, sex, season, lifestyle factors, diseases and biomarkers including parathyroid hormone (PTH) were calculated. RESULTS: High levels of 25(OH)D were inversely associated with being prefrail (N=351) or frail (N=38) in the model adjusted for age, sex, season and lifestyle factors. Compared to levels <15 ng/ml, odds ratios (ORs) (95% confidence intervals (CIs) were 0.52 (0.34-0.78) for levels of 15-<20 ng/ml, 0.55 (0.37-0.81) for levels of 20-<30 ng/ml and 0.32 (0.21-0.51) for levels ≥ 30 ng/ml. Additional adjustment for potential mediators including PTH only slightly attenuated these associations. For single frailty-components, significantly decreased ORs were found for exhaustion, physical inactivity and slowness comparing 25(OH)D levels ≥ 30 ng/ml with levels <15 ng/ml. CONCLUSION: Subjects with 25(OH)D serum levels ≥ 15 ng/ml were less frequently prefrail or frail.
OBJECTIVES: Older adults often suffer from vitamin Ddeficiency and from the frailty syndrome charac-terized by different physical limitations, complicating independent everyday life. Previous studies have suggested a relationship between vitamin D status and the frailty syndrome, but results have been partly inconsistent, particularly regarding the shape of the association. Therefore, our aim was to further assess the association of 25-hydroxyvitamin D (25(OH)D) serum levels and frailty in older participants. DESIGN: Cross-sectional population-based study. PARTICIPANTS: The study population included 478 men and 462 women of the KORA (COoperative health research in the Region of Augsburg)-Age study born before 1944 examined in 2009. MEASUREMENTS: Classification of participants into different frailty states was performed according to the following criteria: weight loss, exhaustion, physical inactivity, slowness, and weakness. PARTICIPANTS who met 1-2 or ≥ 3 of the 5 criteria were classified as prefrail or frail, respectively. Total 25(OH)D was measured in non-fasting serum samples with an enhanced chemiluminescence immunoassay. Sequential logistic regression models adjusted for age, sex, season, lifestyle factors, diseases and biomarkers including parathyroid hormone (PTH) were calculated. RESULTS: High levels of 25(OH)D were inversely associated with being prefrail (N=351) or frail (N=38) in the model adjusted for age, sex, season and lifestyle factors. Compared to levels <15 ng/ml, odds ratios (ORs) (95% confidence intervals (CIs) were 0.52 (0.34-0.78) for levels of 15-<20 ng/ml, 0.55 (0.37-0.81) for levels of 20-<30 ng/ml and 0.32 (0.21-0.51) for levels ≥ 30 ng/ml. Additional adjustment for potential mediators including PTH only slightly attenuated these associations. For single frailty-components, significantly decreased ORs were found for exhaustion, physical inactivity and slowness comparing 25(OH)D levels ≥ 30 ng/ml with levels <15 ng/ml. CONCLUSION: Subjects with 25(OH)D serum levels ≥ 15 ng/ml were less frequently prefrail or frail.
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: Kristine E Ensrud; Susan K Ewing; Lisa Fredman; Marc C Hochberg; Jane A Cauley; Teresa A Hillier; Steven R Cummings; Kristine Yaffe; Peggy M Cawthon Journal: J Clin Endocrinol Metab Date: 2010-12 Impact factor: 5.958
Authors: Brian Buta; Parichoy Pal Choudhury; Qian-Li Xue; Paulo Chaves; Karen Bandeen-Roche; Michelle Shardell; Richard D Semba; Jeremy Walston; Erin D Michos; Lawrence J Appel; Mara McAdams-DeMarco; Alden Gross; Sevil Yasar; Luigi Ferrucci; Linda P Fried; Rita Rastogi Kalyani Journal: J Am Geriatr Soc Date: 2016-12-23 Impact factor: 5.562
Authors: C Trevisan; N Veronese; L Berton; S Carraro; F Bolzetta; M De Rui; F Miotto; E M Inelmen; A Coin; E Perissinotto; E Manzato; G Sergi Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Romy Conzade; Wolfgang Koenig; Margit Heier; Andrea Schneider; Eva Grill; Annette Peters; Barbara Thorand Journal: Nutrients Date: 2017-11-23 Impact factor: 5.717