Literature DB >> 25722234

What does it take to produce a breakthrough drug?

Dirk Calcoen1, Laura Elias1, Xiaomeng Yu1.   

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Year:  2015        PMID： 25722234     DOI： 10.1038/nrd4570

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  14 in total

Review 1.  Protective alleles and modifier variants in human health and disease.

Authors:  Andrew R Harper; Shalini Nayee; Eric J Topol
Journal:  Nat Rev Genet       Date:  2015-10-27       Impact factor: 53.242

2.  Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation.

Authors:  Michael J Doerksen; Robert S Jones; Michael W H Coughtrie; Abby C Collier
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2020-12-19       Impact factor: 2.441

Review 3.  Advancing Drug Discovery and Development Using Molecular Imaging (ADDMI): an Interest Group of the World Molecular Imaging Society and an Inaugural Session on Positron Emission Tomography (PET).

Authors:  Shil Patel; Karl Schmidt; Jacob Hesterman; Jack Hoppin
Journal:  Mol Imaging Biol       Date:  2017-06       Impact factor: 3.488

Review 4.  Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.

Authors:  Naiem T Issa; Henri Wathieu; Abiola Ojo; Stephen W Byers; Sivanesan Dakshanamurthy
Journal:  Curr Drug Metab       Date:  2017       Impact factor: 3.731

Review 5.  The involvement of microglia in Alzheimer's disease: a new dog in the fight.

Authors:  Zachery Moore; Juliet M Taylor; Peter J Crack
Journal:  Br J Pharmacol       Date:  2018-12-18       Impact factor: 8.739

6.  APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Authors:  Yuan-Ta Lin; Jinsoo Seo; Fan Gao; Heather M Feldman; Hsin-Lan Wen; Jay Penney; Hugh P Cam; Elizabeta Gjoneska; Waseem K Raja; Jemmie Cheng; Richard Rueda; Oleg Kritskiy; Fatema Abdurrob; Zhuyu Peng; Blerta Milo; Chung Jong Yu; Sara Elmsaouri; Dilip Dey; Tak Ko; Bruce A Yankner; Li-Huei Tsai
Journal:  Neuron       Date:  2018-05-31       Impact factor: 17.173

7.  Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors: 
Journal:  Lancet Neurol       Date:  2018-11-26       Impact factor: 44.182

8.  Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups.

Authors:  Robert Perneczky; Gerd Kempermann; Amos D Korczyn; Fiona E Matthews; M Arfan Ikram; Nikolaos Scarmeas; Gael Chetelat; Yaakov Stern; Michael Ewers
Journal:  BMC Med       Date:  2019-02-27       Impact factor: 8.775

9.  Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks.

Authors:  Daniel Simão; Ana P Terrasso; Ana P Teixeira; Catarina Brito; Ursula Sonnewald; Paula M Alves
Journal:  Sci Rep       Date:  2016-09-13       Impact factor: 4.379

10.  Improving the odds of drug development success through human genomics: modelling study.

Authors:  Aroon D Hingorani; Valerie Kuan; Chris Finan; Felix A Kruger; Anna Gaulton; Sandesh Chopade; Reecha Sofat; Raymond J MacAllister; John P Overington; Harry Hemingway; Spiros Denaxas; David Prieto; Juan Pablo Casas
Journal:  Sci Rep       Date:  2019-12-11       Impact factor: 4.379
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