Literature DB >> 28417265

Advancing Drug Discovery and Development Using Molecular Imaging (ADDMI): an Interest Group of the World Molecular Imaging Society and an Inaugural Session on Positron Emission Tomography (PET).

Shil Patel1, Karl Schmidt2, Jacob Hesterman3, Jack Hoppin3.   

Abstract

Multi-modality molecular imaging techniques have expanded the role of imaging biomarkers in the pharmaceutical industry and are beginning to streamline the drug discovery and development process. The World Molecular Imaging Society (WMIS) serves as a forum for discussing innovative and exploratory multi-modal, interdisciplinary molecular imaging research with a mission of bridging the gap between pathology and in vivo imaging. To formalize the role of the WMIS in pharmaceutical research efforts, members of the society have formed an interest group entitled Advancing Drug Discovery and Development using Molecular Imaging (ADDMI). The ADDMI interest group launched their efforts at the 2016 World Molecular Imaging Congress by hosting a session of invited lectures on translational positron emission tomography (PET) imaging in the central nervous system. This article provides a synopsis of those lectures and frames the role of translational imaging biomarker strategies in the drug discovery and development process.

Keywords:  Drug research and development; Imaging biomarkers; Molecular imaging; Positron emission tomography

Mesh:

Substances:

Year:  2017        PMID: 28417265     DOI: 10.1007/s11307-017-1085-7

Source DB:  PubMed          Journal:  Mol Imaging Biol        ISSN: 1536-1632            Impact factor:   3.488


  46 in total

1.  Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ).

Authors:  Olof Solin; Olli Eskola; Terence G Hamill; Jörgen Bergman; Pertti Lehikoinen; Tove Grönroos; Sarita Forsback; Merja Haaparanta; Tapio Viljanen; Christine Ryan; Raymond Gibson; Gerard Kieczykowski; Jarmo Hietala; Richard Hargreaves; H Donald Burns
Journal:  Mol Imaging Biol       Date:  2004 Nov-Dec       Impact factor: 3.488

Review 2.  The role of molecular imaging in modern drug development.

Authors:  Lídia Cunha; Krisztián Szigeti; Domokos Mathé; Luís F Metello
Journal:  Drug Discov Today       Date:  2014-01-13       Impact factor: 7.851

3.  First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: proof of concept with the tau imaging agent [18F]T807.

Authors:  Steven H Liang; Daniel L Yokell; Marc D Normandin; Peter A Rice; Raul N Jackson; Timothy M Shoup; Thomas J Brady; Georges El Fakhri; Thomas L Collier; Neil Vasdev
Journal:  Mol Imaging       Date:  2014       Impact factor: 4.488

4.  Chronic Traumatic Encephalopathy in Athletes Involved with High-impact Sports.

Authors:  Cyrus Safinia; Eric M Bershad; H Brent Clark; Karen SantaCruz; Naila Alakbarova; Jose I Suarez; Afshin A Divani
Journal:  J Vasc Interv Neurol       Date:  2016-10

5.  Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease.

Authors:  Victor L Villemagne; Rachel S Mulligan; Svetlana Pejoska; Kevin Ong; Gareth Jones; Graeme O'Keefe; J Gordon Chan; Kenneth Young; Henri Tochon-Danguy; Colin L Masters; Christopher C Rowe
Journal:  Eur J Nucl Med Mol Imaging       Date:  2012-03-08       Impact factor: 9.236

6.  Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

Authors:  Abbas M Walji; Eric D Hostetler; Harold Selnick; Zhizhen Zeng; Patricia Miller; Idriss Bennacef; Cristian Salinas; Brett Connolly; Liza Gantert; Marie Holahan; Stacey O'Malley; Mona Purcell; Kerry Riffel; Jing Li; Jaume Balsells; Julie A OBrien; Stacey Melquist; Aileen Soriano; Xiaoping Zhang; Aimie Ogawa; Serena Xu; Elizabeth Joshi; Joseph Della Rocca; Fred J Hess; Joel Schachter; David Hesk; David Schenk; Arie Struyk; Kerim Babaoglu; Talakad G Lohith; Yaode Wang; Kun Yang; Jianmin Fu; Jeffrey L Evelhoch; Paul J Coleman
Journal:  J Med Chem       Date:  2016-05-05       Impact factor: 7.446

7.  Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.

Authors:  Eric D Hostetler; Abbas M Walji; Zhizhen Zeng; Patricia Miller; Idriss Bennacef; Cristian Salinas; Brett Connolly; Liza Gantert; Hyking Haley; Marie Holahan; Mona Purcell; Kerry Riffel; Talakad G Lohith; Paul Coleman; Aileen Soriano; Aimie Ogawa; Serena Xu; Xiaoping Zhang; Elizabeth Joshi; Joseph Della Rocca; David Hesk; David J Schenk; Jeffrey L Evelhoch
Journal:  J Nucl Med       Date:  2016-05-26       Impact factor: 10.057

Review 8.  Assessing antibody pharmacokinetics in mice with in vivo imaging.

Authors:  Jack Hoppin; Kelly Davis Orcutt; Jacob Y Hesterman; Matthew D Silva; Dengfeng Cheng; Christian Lackas; Mary Rusckowski
Journal:  J Pharmacol Exp Ther       Date:  2011-02-11       Impact factor: 4.030

Review 9.  Dopamine receptors and brain function.

Authors:  M Jaber; S W Robinson; C Missale; M G Caron
Journal:  Neuropharmacology       Date:  1996       Impact factor: 5.250

10.  CSF-tau, CSF-Abeta1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity.

Authors:  S Ganzer; S Arlt; V Schoder; C Buhmann; E-M Mandelkow; U Finckh; U Beisiegel; D Naber; T Müller-Thomsen
Journal:  J Neural Transm (Vienna)       Date:  2003-10       Impact factor: 3.575

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  1 in total

Review 1.  PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective.

Authors:  Sridhar Goud Nerella; Priti Singh; Tulja Sanam; Chander Singh Digwal
Journal:  Front Med (Lausanne)       Date:  2022-02-28
  1 in total

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