Literature DB >> 25717114

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

Matthew D Hirschey1, Yingming Zhao2.   

Abstract

Protein acetylation is a well-studied regulatory mechanism for several cellular processes, ranging from gene expression to metabolism. Recent discoveries of new post-translational modifications, including malonylation, succinylation, and glutarylation, have expanded our understanding of the types of modifications found on proteins. These three acidic lysine modifications are structurally similar but have the potential to regulate different proteins in different pathways. The deacylase sirtuin 5 (SIRT5) catalyzes the removal of these modifications from a wide range of proteins in different subcellular compartments. Here, we review these new modifications, their regulation by SIRT5, and their emerging role in cellular regulation and diseases.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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Year:  2015        PMID： 25717114      PMCID： PMC4563717          DOI： 10.1074/mcp.R114.046664

Source DB:  PubMed          Journal:  Mol Cell Proteomics        ISSN： 1535-9476            Impact factor:   5.911


  54 in total

1.  Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis.

Authors:  J P Bonnefont; D Chretien; P Rustin; B Robinson; A Vassault; J Aupetit; C Charpentier; D Rabier; J M Saudubray; A Munnich
Journal:  J Pediatr       Date:  1992-08       Impact factor: 4.406

Review 2.  HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention.

Authors:  X-J Yang; E Seto
Journal:  Oncogene       Date:  2007-08-13       Impact factor: 9.867

Review 3.  Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.

Authors:  Paul A Marks; Ronald Breslow
Journal:  Nat Biotechnol       Date:  2007-01       Impact factor: 54.908

4.  Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.

Authors:  Matthew D Hirschey
Journal:  Cell Metab       Date:  2011-11-17       Impact factor: 27.287

5.  Identification of lysine succinylation as a new post-translational modification.

Authors:  Zhihong Zhang; Minjia Tan; Zhongyu Xie; Lunzhi Dai; Yue Chen; Yingming Zhao
Journal:  Nat Chem Biol       Date:  2010-12-12       Impact factor: 15.040

6.  Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

Authors:  Qijun Wang; Yakun Zhang; Chen Yang; Hui Xiong; Yan Lin; Jun Yao; Hong Li; Lu Xie; Wei Zhao; Yufeng Yao; Zhi-Bin Ning; Rong Zeng; Yue Xiong; Kun-Liang Guan; Shimin Zhao; Guo-Ping Zhao
Journal:  Science       Date:  2010-02-19       Impact factor: 47.728

Review 7.  The sirtuin family's role in aging and age-associated pathologies.

Authors:  Jessica A Hall; John E Dominy; Yoonjin Lee; Pere Puigserver
Journal:  J Clin Invest       Date:  2013-03-01       Impact factor: 14.808

8.  SIRT3 reverses aging-associated degeneration.

Authors:  Katharine Brown; Stephanie Xie; Xiaolei Qiu; Mary Mohrin; Jiyung Shin; Yufei Liu; Dan Zhang; David T Scadden; Danica Chen
Journal:  Cell Rep       Date:  2013-01-31       Impact factor: 9.423

9.  Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Authors:  Jintang Du; Yeyun Zhou; Xiaoyang Su; Jiu Jiu Yu; Saba Khan; Hong Jiang; Jungwoo Kim; Jimin Woo; Jun Huyn Kim; Brian Hyun Choi; Bin He; Wei Chen; Sheng Zhang; Richard A Cerione; Johan Auwerx; Quan Hao; Hening Lin
Journal:  Science       Date:  2011-11-11       Impact factor: 47.728

10.  The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.

Authors:  Bjorn Schwer; Brian J North; Roy A Frye; Melanie Ott; Eric Verdin
Journal:  J Cell Biol       Date:  2002-08-19       Impact factor: 10.539
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  145 in total

1.  Acetyl-ed question in mitochondrial biology?

Authors:  David B Lombard; Banaja P Dash; Surinder Kumar
Journal:  EMBO J       Date:  2015-09-14       Impact factor: 11.598

Review 2.  Lipid-associated metabolic signalling networks in pancreatic beta cell function.

Authors:  Marc Prentki; Barbara E Corkey; S R Murthy Madiraju
Journal:  Diabetologia       Date:  2019-08-19       Impact factor: 10.122

3.  A Versatile Approach for Site-Specific Lysine Acylation in Proteins.

Authors:  Zhipeng A Wang; Yadagiri Kurra; Xin Wang; Yu Zeng; Yan-Jiun Lee; Vangmayee Sharma; Hening Lin; Susie Y Dai; Wenshe R Liu
Journal:  Angew Chem Int Ed Engl       Date:  2017-01-02       Impact factor: 15.336

4.  A liquid chromatography tandem mass spectroscopy approach for quantification of protein methylation stoichiometry.

Authors:  Grace L Cooper; Carol J Huseby; Claire N Chandler; Jean-Christophe Cocuron; Ana P Alonso; Jeff Kuret
Journal:  Anal Biochem       Date:  2018-03-15       Impact factor: 3.365

5.  Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration.

Authors:  Courtney J Banks; Nathan W Rodriguez; Kyle R Gashler; Rushika R Pandya; Jeffrey B Mortenson; Matthew D Whited; Erik J Soderblom; J Will Thompson; M Arthur Moseley; Amit R Reddi; Jeffery S Tessem; Matthew P Torres; Benjamin T Bikman; Joshua L Andersen
Journal:  Mol Cell Biol       Date:  2017-09-26       Impact factor: 4.272

6.  Emerging Roles for SIRT5 in Metabolism and Cancer.

Authors:  Lauren R Bringman-Rodenbarger; Angela H Guo; Costas A Lyssiotis; David B Lombard
Journal:  Antioxid Redox Signal       Date:  2017-10-26       Impact factor: 8.401

Review 7.  Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.

Authors:  Bojana Ristic; Yangzom D Bhutia; Vadivel Ganapathy
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-05-13       Impact factor: 10.680

8.  Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.

Authors:  Hadi R Ali; Mohammed A Assiri; Peter S Harris; Cole R Michel; Youngho Yun; John O Marentette; Frank K Huynh; David J Orlicky; Colin T Shearn; Laura M Saba; Richard Reisdorph; Nichole Reisdorph; Matthew D Hirschey; Kristofer S Fritz
Journal:  J Proteome Res       Date:  2019-01-31       Impact factor: 4.466

9.  Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework.

Authors:  Yanju Zhang; Ruopeng Xie; Jiawei Wang; André Leier; Tatiana T Marquez-Lago; Tatsuya Akutsu; Geoffrey I Webb; Kuo-Chen Chou; Jiangning Song
Journal:  Brief Bioinform       Date:  2019-11-27       Impact factor: 11.622

10.  Large-scale comparative assessment of computational predictors for lysine post-translational modification sites.

Authors:  Zhen Chen; Xuhan Liu; Fuyi Li; Chen Li; Tatiana Marquez-Lago; André Leier; Tatsuya Akutsu; Geoffrey I Webb; Dakang Xu; Alexander Ian Smith; Lei Li; Kuo-Chen Chou; Jiangning Song
Journal:  Brief Bioinform       Date:  2019-11-27       Impact factor: 11.622
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