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Literature DB >> 22100408

Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.

Abstract

Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins.

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 22100408 PMCID： PMC3830953 DOI： 10.1016/j.cmet.2011.10.006

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

10 in total

1. The first identification of lysine malonylation substrates and its regulatory enzyme.

Authors: Chao Peng; Zhike Lu; Zhongyu Xie; Zhongyi Cheng; Yue Chen; Minjia Tan; Hao Luo; Yi Zhang; Wendy He; Ke Yang; Bernadette M M Zwaans; Daniel Tishkoff; Linh Ho; David Lombard; Tong-Chuan He; Junbiao Dai; Eric Verdin; Yang Ye; Yingming Zhao
Journal: Mol Cell Proteomics Date: 2011-09-09 Impact factor: 5.911

2. Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver.

Authors: P A Quant; P K Tubbs; M D Brand
Journal: Biochem J Date: 1989-08-15 Impact factor: 3.857

3. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.

Authors: R A Frye
Journal: Biochem Biophys Res Commun Date: 2000-07-05 Impact factor: 3.575

4. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

Authors: Brian J North; Brett L Marshall; Margie T Borra; John M Denu; Eric Verdin
Journal: Mol Cell Date: 2003-02 Impact factor: 17.970

Review 5. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Authors: Shin-ichiro Imai; Leonard Guarente
Journal: Trends Pharmacol Sci Date: 2010-03-11 Impact factor: 14.819

6. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Authors: Marcia C Haigis; Raul Mostoslavsky; Kevin M Haigis; Kamau Fahie; Danos C Christodoulou; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Margaret Karow; Gil Blander; Cynthia Wolberger; Tomas A Prolla; Richard Weindruch; Frederick W Alt; Leonard Guarente
Journal: Cell Date: 2006-09-08 Impact factor: 41.582

7. Identification of lysine succinylation as a new post-translational modification.

Authors: Zhihong Zhang; Minjia Tan; Zhongyu Xie; Lunzhi Dai; Yue Chen; Yingming Zhao
Journal: Nat Chem Biol Date: 2010-12-12 Impact factor: 15.040

Review 8. Recent progress in the biology and physiology of sirtuins.

Authors: Toren Finkel; Chu-Xia Deng; Raul Mostoslavsky
Journal: Nature Date: 2009-07-30 Impact factor: 49.962

9. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Authors: Takashi Nakagawa; David J Lomb; Marcia C Haigis; Leonard Guarente
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

10. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Authors: Jintang Du; Yeyun Zhou; Xiaoyang Su; Jiu Jiu Yu; Saba Khan; Hong Jiang; Jungwoo Kim; Jimin Woo; Jun Huyn Kim; Brian Hyun Choi; Bin He; Wei Chen; Sheng Zhang; Richard A Cerione; Johan Auwerx; Quan Hao; Hening Lin
Journal: Science Date: 2011-11-11 Impact factor: 47.728

10 in total

42 in total

1. The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Authors: Michael N Davies; Lilja Kjalarsdottir; J Will Thompson; Laura G Dubois; Robert D Stevens; Olga R Ilkayeva; M Julia Brosnan; Timothy P Rolph; Paul A Grimsrud; Deborah M Muoio
Journal: Cell Rep Date: 2015-12-31 Impact factor: 9.423

2. Oxygen flux analysis to understand the biological function of sirtuins.

Authors: Dongning Wang; Michelle F Green; Eoin McDonnell; Matthew D Hirschey
Journal: Methods Mol Biol Date: 2013

3. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.

Authors: Sivakama S Bharathi; Yuxun Zhang; Al-Walid Mohsen; Radha Uppala; Manimalha Balasubramani; Emanuel Schreiber; Guy Uechi; Megan E Beck; Matthew J Rardin; Jerry Vockley; Eric Verdin; Bradford W Gibson; Matthew D Hirschey; Eric S Goetzman
Journal: J Biol Chem Date: 2013-10-11 Impact factor: 5.157

4. Targeting sirtuins for the treatment of diabetes.

Authors: Frank K Huynh; Kathleen A Hershberger; Matthew D Hirschey
Journal: Diabetes Manag (Lond) Date: 2013-05-01

5. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.

Authors: Yi-Ping Wang; Li-Sha Zhou; Yu-Zheng Zhao; Shi-Wen Wang; Lei-Lei Chen; Li-Xia Liu; Zhi-Qiang Ling; Fu-Jun Hu; Yi-Ping Sun; Jing-Ye Zhang; Chen Yang; Yi Yang; Yue Xiong; Kun-Liang Guan; Dan Ye
Journal: EMBO J Date: 2014-04-25 Impact factor: 11.598

6. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Authors: Martina Wirth; Samir Karaca; Dirk Wenzel; Linh Ho; Daniel Tishkoff; David B Lombard; Eric Verdin; Henning Urlaub; Monika Jedrusik-Bode; Wolfgang Fischle
Journal: Mitochondrion Date: 2013-02-21 Impact factor: 4.160

10. Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.

Authors: Hao Qi; Xiaoyan Shi; Miao Yu; Boya Liu; Minghui Liu; Shi Song; Shuaiyi Chen; Junhua Zou; Wei-Guo Zhu; Jianyuan Luo
Journal: J Biol Chem Date: 2018-10-03 Impact factor: 5.157