BACKGROUND AND AIMS: A landfill, an incinerator, and a refinery plant have been operating since the early 1960s in a contaminated site located in the suburb of Rome (Italy). To evaluate their potential health effects, a population-based retrospective cohort study was conducted using dispersion modeling for exposure assessment. METHODS: A fixed cohort was enrolled in the Rome Longitudinal Study in 2001, mortality and hospitalizations were followed-up until 2010. Exposure assessments to the landfill (H2S), the incinerator (PM10), and the refinery plant (SOX) were performed for each subject using a Lagrangian dispersion model. Individual and small-area variables were available (including exposures levels to NO2 from traffic and diesel trucks). Cox regression analysis was performed (hazard ratios, HRs, 95% CI) using linear terms for the exposures (5th-95th percentiles difference). Single and bi-pollutant models were run. RESULTS: The cohort included 85,559 individuals. The estimated annual average exposures levels were correlated. H2S from the landfill was associated with cardiovascular hospital admissions in both genders (HR 1.04 95% CI 1.00-1.09 in women); PM10 from the incinerator was associated with pancreatic cancer mortality in both genders (HR 1.40 95% CI 1.03-1.90 in men, HR 1.47 95% CI 1.12-1.93 in women) and with breast morbidity in women (HR 1.13 95% CI 1.00-1.27). SOx from the refinery was associated with laryngeal cancer mortality in women (HR 4.99 95% CI 1.64-15.9) and respiratory hospital admissions (HR 1.13 95% CI 1.01-1.27). CONCLUSIONS: We found an association of the pollution sources with some cancer forms and cardio-respiratory diseases. Although there was a high correlation between the estimated exposures, an indication of specific effects from the different sources emerged.
BACKGROUND AND AIMS: A landfill, an incinerator, and a refinery plant have been operating since the early 1960s in a contaminated site located in the suburb of Rome (Italy). To evaluate their potential health effects, a population-based retrospective cohort study was conducted using dispersion modeling for exposure assessment. METHODS: A fixed cohort was enrolled in the Rome Longitudinal Study in 2001, mortality and hospitalizations were followed-up until 2010. Exposure assessments to the landfill (H2S), the incinerator (PM10), and the refinery plant (SOX) were performed for each subject using a Lagrangian dispersion model. Individual and small-area variables were available (including exposures levels to NO2 from traffic and diesel trucks). Cox regression analysis was performed (hazard ratios, HRs, 95% CI) using linear terms for the exposures (5th-95th percentiles difference). Single and bi-pollutant models were run. RESULTS: The cohort included 85,559 individuals. The estimated annual average exposures levels were correlated. H2S from the landfill was associated with cardiovascular hospital admissions in both genders (HR 1.04 95% CI 1.00-1.09 in women); PM10 from the incinerator was associated with pancreatic cancer mortality in both genders (HR 1.40 95% CI 1.03-1.90 in men, HR 1.47 95% CI 1.12-1.93 in women) and with breast morbidity in women (HR 1.13 95% CI 1.00-1.27). SOx from the refinery was associated with laryngeal cancer mortality in women (HR 4.99 95% CI 1.64-15.9) and respiratory hospital admissions (HR 1.13 95% CI 1.01-1.27). CONCLUSIONS: We found an association of the pollution sources with some cancer forms and cardio-respiratory diseases. Although there was a high correlation between the estimated exposures, an indication of specific effects from the different sources emerged.
Authors: Ole Raaschou-Nielsen; Gerard Hoek; Jie Chen; Sophia Rodopoulou; Maciej Strak; Kees de Hoogh; Tahir Taj; Aslak Harbo Poulsen; Zorana J Andersen; Tom Bellander; Jørgen Brandt; Emanuel Zitt; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; W M Monique Verschuren; Jeanette T Jørgensen; Klea Katsouyanni; Matthias Ketzel; Anton Lager; Karin Leander; Shuo Liu; Petter Ljungman; Gianluca Severi; Marie-Christine Boutron-Ruault; Patrik K E Magnusson; Gabriele Nagel; Göran Pershagen; Annette Peters; Debora Rizzuto; Yvonne T van der Schouw; Evangelia Samoli; Mette Sørensen; Massimo Stafoggia; Anne Tjønneland; Gudrun Weinmayr; Kathrin Wolf; Bert Brunekreef Journal: Br J Cancer Date: 2022-02-16 Impact factor: 9.075
Authors: David Bogumil; Anna H Wu; Daniel Stram; Juan Yang; Chiu-Chen Tseng; Loïc Le Marchand; Jun Wu; Iona Cheng; Veronica Wendy Setiawan Journal: Environ Res Date: 2021-06-30 Impact factor: 6.498
Authors: Doug Brugge; Shir Lerman Ginzburg; Neelakshi Hudda; Linda Sprague Martinez; Leigh Meunier; Scott P Hersey; Ira Hochman; Douglas I Walker; Ben Echevarria; Mohan Thanikachalam; John L Durant; Wig Zamore; Misha Eliasziw Journal: Contemp Clin Trials Date: 2021-07-28 Impact factor: 2.261
Authors: Michelle C Turner; Daniel Krewski; W Ryan Diver; C Arden Pope; Richard T Burnett; Michael Jerrett; Julian D Marshall; Susan M Gapstur Journal: Environ Health Perspect Date: 2017-08-21 Impact factor: 9.031