| Literature DB >> 25688525 |
Jongsik Kim, Adeel Ahmad, Joanne Li, Marina Marjanovic, Eric J Chaney, Kenneth S Suslick, Stephen A Boppart.
Abstract
We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM-OCT signal from the aorta samples specimens injected with targeted MSs.Entities:
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Year: 2016 PMID: 25688525 PMCID: PMC4996077 DOI: 10.1002/jbio.201400128
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207