So Yeon Kong1, Michael Goodman2, Suzanne Judd3, Roberd M Bostick2, W Dana Flanders4, William McClellan4. 1. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA. Electronic address: soyeon.kong@gmail.com. 2. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA. 3. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL. 4. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Abstract
PURPOSE: We previously proposed an oxidative balance score (OBS) that combines pro- and anti-oxidant exposures to represent the overall oxidative balance status of an individual. In this study, we investigated associations of the OBS with all-cause and cause-specific mortality, and explored alternative OBS weighting methods in the Reasons for Geographic and Racial Differences in Stroke Study cohort. METHODS: The OBS was calculated by combining information from 14 a priori selected pro- and anti-oxidant factors and then divided into quartiles with the lowest quartile (predominance of pro-oxidants) as reference. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals for each OBS category compared with the reference. RESULTS: Over a median 5.8 years of follow-up, 2079 of the 21,031 participants died. The multivariable-adjusted hazard ratios (95% confidence interval) for all-cause, cancer, and noncancer mortality for those in the highest versus the lowest equal-weighting OBS quartile were 0.70 (0.61-0.81), 0.50 (0.37-0.67), and 0.77 (0.66-0.89), respectively (P trend < .01 for all). Similar results were observed with all weighting methods. CONCLUSIONS: These results suggest that individuals with a greater balance of antioxidant to pro-oxidant lifestyle exposures may have lower mortality.
PURPOSE: We previously proposed an oxidative balance score (OBS) that combines pro- and anti-oxidant exposures to represent the overall oxidative balance status of an individual. In this study, we investigated associations of the OBS with all-cause and cause-specific mortality, and explored alternative OBS weighting methods in the Reasons for Geographic and Racial Differences in Stroke Study cohort. METHODS: The OBS was calculated by combining information from 14 a priori selected pro- and anti-oxidant factors and then divided into quartiles with the lowest quartile (predominance of pro-oxidants) as reference. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals for each OBS category compared with the reference. RESULTS: Over a median 5.8 years of follow-up, 2079 of the 21,031 participants died. The multivariable-adjusted hazard ratios (95% confidence interval) for all-cause, cancer, and noncancer mortality for those in the highest versus the lowest equal-weighting OBS quartile were 0.70 (0.61-0.81), 0.50 (0.37-0.67), and 0.77 (0.66-0.89), respectively (P trend < .01 for all). Similar results were observed with all weighting methods. CONCLUSIONS: These results suggest that individuals with a greater balance of antioxidant to pro-oxidant lifestyle exposures may have lower mortality.
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Authors: Titilayo O Ilori; Young Sun Ro; So Yeon Kong; Orlando M Gutierrez; Akinlolu O Ojo; Suzanne E Judd; K M Venkat Narayan; Michael Goodman; Laura Plantinga; William McClellan Journal: Am J Nephrol Date: 2015-11-17 Impact factor: 3.754
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