A-Ra Cho1, Yu-Jin Kwon2, Hyoung-Ji Lim3, Hye Sun Lee4, Sinae Kim4, Jae-Yong Shim5, Hye-Ree Lee1, Yong-Jae Lee6. 1. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, Republic of Korea. 2. Department of Family Medicine, Yong-in Severance Hospital, Yonsei University College of Medicine, Yong-in City, Republic of Korea. 3. Department of Family Medicine, Chungbuk National University Hospital College, Cheongju, Republic of Korea. 4. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. 5. Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 6. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, Republic of Korea. ukyjhome@yuhs.ac.
Abstract
PURPOSE: The oxidative balance score (OBS) comprises dietary and non-dietary lifestyle pro-oxidants and antioxidants. Elevated serum γ-glutamyltransferase (GGT) level has currently emerged as a biomarker of oxidative stress. In this study, we examined whether OBS was inversely associated with serum GGT level and whether OBS could be a useful marker to predict GGT among Korean adults. METHODS: This cross-sectional study was based on data obtained from the 2010 and 2011 Korea National Health and Nutrition Examination Survey. 2087 men and 2071 women were included in final analysis. The OBS was divided into five equal interval categories, and GGT was dichotomized into low and high using its sex-specific median value. Multiple logistic regression analysis was conducted to assess the association between OBS categories and high GGT. RESULTS: Compared with the lowest OBS category as reference, the multivariable adjusted ORs (95% CIs) for the highest OBS category of men and women were 0.05 (0.01-0.19) and 0.27 (0.09-0.78), respectively (p for trend <0.01). CONCLUSION: A higher OBS that indicates a predominance of antioxidant over pro-oxidant exposure was strongly inversely associated with GGT level among Korean adults.
PURPOSE: The oxidative balance score (OBS) comprises dietary and non-dietary lifestyle pro-oxidants and antioxidants. Elevated serum γ-glutamyltransferase (GGT) level has currently emerged as a biomarker of oxidative stress. In this study, we examined whether OBS was inversely associated with serum GGT level and whether OBS could be a useful marker to predict GGT among Korean adults. METHODS: This cross-sectional study was based on data obtained from the 2010 and 2011 Korea National Health and Nutrition Examination Survey. 2087 men and 2071 women were included in final analysis. The OBS was divided into five equal interval categories, and GGT was dichotomized into low and high using its sex-specific median value. Multiple logistic regression analysis was conducted to assess the association between OBS categories and high GGT. RESULTS: Compared with the lowest OBS category as reference, the multivariable adjusted ORs (95% CIs) for the highest OBS category of men and women were 0.05 (0.01-0.19) and 0.27 (0.09-0.78), respectively (p for trend <0.01). CONCLUSION: A higher OBS that indicates a predominance of antioxidant over pro-oxidant exposure was strongly inversely associated with GGT level among Korean adults.
Authors: Sindhu Lakkur; Roberd M Bostick; Douglas Roblin; Murugi Ndirangu; Ike Okosun; Francis Annor; Suzanne Judd; W Dana Flanders; Victoria L Stevens; Michael Goodman Journal: Biomarkers Date: 2014-07-02 Impact factor: 2.658
Authors: So Yeon J Kong; Roberd M Bostick; W Dana Flanders; William M McClellan; Bharat Thyagarajan; Myron D Gross; Suzanne Judd; Michael Goodman Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-01-17 Impact factor: 4.254
Authors: Douglas S Lee; Jane C Evans; Sander J Robins; Peter W Wilson; Irene Albano; Caroline S Fox; Thomas J Wang; Emelia J Benjamin; Ralph B D'Agostino; Ramachandran S Vasan Journal: Arterioscler Thromb Vasc Biol Date: 2006-11-09 Impact factor: 8.311
Authors: Leda Ferraz; Catharina Albiero Bueno Ramos; Antônio Braga; Luis Guillermo Coca Velarde; Kevin M Elias; Neil S Horowitz; Patrícia Fátima Lopes; Ross S Berkowitz Journal: Clinics (Sao Paulo) Date: 2020-07-06 Impact factor: 2.365