Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ironing out VPS34 inhibition.

Literature DB >> 25679028

Ironing out VPS34 inhibition.

Abstract

The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.

Entities: Gene

Mesh：

Substances：

Year: 2015 PMID： 25679028 DOI： 10.1038/ncb3089

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

Review 1. The emerging mechanisms of isoform-specific PI3K signalling.

Authors: Bart Vanhaesebroeck; Julie Guillermet-Guibert; Mariona Graupera; Benoit Bilanges
Journal: Nat Rev Mol Cell Biol Date: 2010-04-09 Impact factor: 94.444

Review 2. Membrane recognition by phospholipid-binding domains.

Authors: Mark A Lemmon
Journal: Nat Rev Mol Cell Biol Date: 2008-02 Impact factor: 94.444

3. Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells.

Authors: Takeshi Asano; Masaaki Komatsu; Yuko Yamaguchi-Iwai; Fuyuki Ishikawa; Noboru Mizushima; Kazuhiro Iwai
Journal: Mol Cell Biol Date: 2011-03-28 Impact factor: 4.272

4. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.

Authors: Baptiste Ronan; Odile Flamand; Lionel Vescovi; Christine Dureuil; Laurence Durand; Florence Fassy; Marie-France Bachelot; Annabelle Lamberton; Magali Mathieu; Thomas Bertrand; Jean-Pierre Marquette; Youssef El-Ahmad; Bruno Filoche-Romme; Laurent Schio; Carlos Garcia-Echeverria; Hélène Goulaouic; Benoit Pasquier
Journal: Nat Chem Biol Date: 2014-10-19 Impact factor: 15.040

5. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Authors: William E Dowdle; Beat Nyfeler; Jane Nagel; Robert A Elling; Shanming Liu; Ellen Triantafellow; Suchithra Menon; Zuncai Wang; Ayako Honda; Gwynn Pardee; John Cantwell; Catherine Luu; Ivan Cornella-Taracido; Edmund Harrington; Peter Fekkes; Hong Lei; Qing Fang; Mary Ellen Digan; Debra Burdick; Andrew F Powers; Stephen B Helliwell; Simon D'Aquin; Julie Bastien; Henry Wang; Dmitri Wiederschain; Jenny Kuerth; Philip Bergman; David Schwalb; Jason Thomas; Savuth Ugwonali; Fred Harbinski; John Tallarico; Christopher J Wilson; Vic E Myer; Jeffery A Porter; Dirksen E Bussiere; Peter M Finan; Mark A Labow; Xiaohong Mao; Lawrence G Hamann; Brendan D Manning; Reginald A Valdez; Thomas Nicholson; Markus Schirle; Mark S Knapp; Erin P Keaney; Leon O Murphy
Journal: Nat Cell Biol Date: 2014-10-19 Impact factor: 28.824

Review 6. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

Authors: Vladimir Rogov; Volker Dötsch; Terje Johansen; Vladimir Kirkin
Journal: Mol Cell Date: 2014-01-23 Impact factor: 17.970

Review 7. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease.

Authors: Lyndsay Murrow; Jayanta Debnath
Journal: Annu Rev Pathol Date: 2012-10-31 Impact factor: 23.472

8. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

Authors: P V Schu; K Takegawa; M J Fry; J H Stack; M D Waterfield; S D Emr
Journal: Science Date: 1993-04-02 Impact factor: 47.728

9. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.

Authors: Joseph D Mancias; Xiaoxu Wang; Steven P Gygi; J Wade Harper; Alec C Kimmelman
Journal: Nature Date: 2014-03-30 Impact factor: 49.962

10. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Authors: Ruzica Bago; Nazma Malik; Michael J Munson; Alan R Prescott; Paul Davies; Eeva Sommer; Natalia Shpiro; Richard Ward; Darren Cross; Ian G Ganley; Dario R Alessi
Journal: Biochem J Date: 2014-11-01 Impact factor: 3.857

10 in total

1. Autophagy Enhances Memory Erasure through Synaptic Destabilization.

Authors: Mohammad Shehata; Kareem Abdou; Kiriko Choko; Mina Matsuo; Hirofumi Nishizono; Kaoru Inokuchi
Journal: J Neurosci Date: 2018-03-19 Impact factor: 6.167

2. Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival.

Authors: D Dayde; M Guerard; P Perron; A-S Hatat; C Barrial; B Eymin; S Gazzeri
Journal: Oncogene Date: 2015-12-21 Impact factor: 9.867

Review 3. Autophagy in Cancer: Regulation by Small Molecules.

Authors: Allison S Limpert; Lester J Lambert; Nicole A Bakas; Nicole Bata; Sonja N Brun; Reuben J Shaw; Nicholas D P Cosford
Journal: Trends Pharmacol Sci Date: 2018-12 Impact factor: 14.819

4. An autophagy-independent function for Beclin 1 in cancer.

Authors: Rasika A Rohatgi; Leslie M Shaw
Journal: Mol Cell Oncol Date: 2015-04-14

5. Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus.

Authors: Zhike Feng; Kai Xu; Nikolay Kovalev; Peter D Nagy
Journal: PLoS Pathog Date: 2019-01-09 Impact factor: 6.823

6. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.

Authors: Muhammad Zaeem Noman; Santiago Parpal; Kris Van Moer; Malina Xiao; Yasmin Yu; Jenny Viklund; Angelo De Milito; Meriem Hasmim; Martin Andersson; Ravi K Amaravadi; Jessica Martinsson; Guy Berchem; Bassam Janji
Journal: Sci Adv Date: 2020-04-29 Impact factor: 14.136

Review 7. Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers.

Authors: Martina Raudenska; Jan Balvan; Michal Masarik
Journal: Mol Cancer Date: 2021-10-27 Impact factor: 27.401