Literature DB >> 26998512

An autophagy-independent function for Beclin 1 in cancer.

Rasika A Rohatgi1, Leslie M Shaw1.   

Abstract

The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.

Entities:  

Year:  2015        PMID： 26998512      PMCID： PMC4792009          DOI： 10.1080/23723556.2015.1030539

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

Authors:  Sigrid B Thoresen; Nina Marie Pedersen; Knut Liestøl; Harald Stenmark
Journal:  Exp Cell Res       Date:  2010-07-17       Impact factor: 3.905

2.  Ironing out VPS34 inhibition.

Authors:  Timothy Marsh; Jayanta Debnath
Journal:  Nat Cell Biol       Date:  2015-01       Impact factor: 28.824

3.  Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Authors:  X H Liang; S Jackson; M Seaman; K Brown; B Kempkes; H Hibshoosh; B Levine
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

Review 4.  Beclin1: a role in membrane dynamics and beyond.

Authors:  Ellen Wirawan; Saskia Lippens; Tom Vanden Berghe; Alessandra Romagnoli; Gian Maria Fimia; Mauro Piacentini; Peter Vandenabeele
Journal:  Autophagy       Date:  2012-01-01       Impact factor: 16.016

5.  Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Authors:  Zhenyu Yue; Shengkan Jin; Chingwen Yang; Arnold J Levine; Nathaniel Heintz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

6.  Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

Authors:  Xueping Qu; Jie Yu; Govind Bhagat; Norihiko Furuya; Hanina Hibshoosh; Andrea Troxel; Jeffrey Rosen; Eeva-Liisa Eskelinen; Noboru Mizushima; Yoshinori Ohsumi; Giorgio Cattoretti; Beth Levine
Journal:  J Clin Invest       Date:  2003-11-24       Impact factor: 14.808

7.  Low expression of Beclin 1 and elevated expression of HIF-1α refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer.

Authors:  Min Dong; Xiang-bo Wan; Zhong Yu Yuan; Li Wei; Xin Juan Fan; Tian-tian Wang; Yan Chun Lv; Xing Li; Zhan-hong Chen; Jie Chen; Qu Lin; Jing-yun Wen; Xiao-kun Ma; Quentin Liu; Xiang Yuan Wu
Journal:  Med Oncol       Date:  2013-02-14       Impact factor: 3.064

8.  Beclin 1 regulates growth factor receptor signaling in breast cancer.

Authors:  R A Rohatgi; J Janusis; D Leonard; K D Bellvé; K E Fogarty; E H Baehrecke; S Corvera; L M Shaw
Journal:  Oncogene       Date:  2015-02-02       Impact factor: 9.867

9.  Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

Authors:  Nicole C McKnight; Yun Zhong; Mitchell S Wold; Shiaoching Gong; Greg R Phillips; Zhixun Dou; Yanxiang Zhao; Nathaniel Heintz; Wei-Xing Zong; Zhenyu Yue
Journal:  PLoS Genet       Date:  2014-10-02       Impact factor: 5.917

10.  Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma.

Authors:  Juan Wang; Xin-Liang Pan; Li-Jie Ding; Da-Yu Liu; Tong Jin
Journal:  PLoS One       Date:  2013-07-25       Impact factor: 3.240
  10 in total
  7 in total

Review 1.  Targeting autophagy in lymphomas: a double-edged sword?

Authors:  Han Zhang
Journal:  Int J Hematol       Date:  2018-01-27       Impact factor: 2.490

Review 2.  Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades.

Authors:  Fahd Boutouja; Rebecca Brinkmeier; Thomas Mastalski; Fouzi El Magraoui; Harald W Platta
Journal:  Int J Mol Sci       Date:  2017-11-27       Impact factor: 5.923

Review 3.  Role and Mechanisms of RAGE-Ligand Complexes and RAGE-Inhibitors in Cancer Progression.

Authors:  Ali H El-Far; Grazyna Sroga; Soad K Al Jaouni; Shaker A Mousa
Journal:  Int J Mol Sci       Date:  2020-05-20       Impact factor: 5.923

4.  Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells.

Authors:  Jialin Zhu; Yongsong Cai; Ke Xu; Xiaoyu Ren; Jian Sun; Shemin Lu; Jinghong Chen; Peng Xu
Journal:  Oncol Rep       Date:  2018-07-25       Impact factor: 3.906

Review 5.  Autophagy and disease: unanswered questions.

Authors:  Ying Yang; Daniel J Klionsky
Journal:  Cell Death Differ       Date:  2020-01-03       Impact factor: 15.828

Review 6.  Genes involved in the regulation of different types of autophagy and their participation in cancer pathogenesis.

Authors:  Martyna Bednarczyk; Nikola Zmarzły; Beniamin Grabarek; Urszula Mazurek; Małgorzata Muc-Wierzgoń
Journal:  Oncotarget       Date:  2018-09-28

7.  Exercise Mitigates the Loss of Muscle Mass by Attenuating the Activation of Autophagy during Severe Energy Deficit.

Authors:  Marcos Martin-Rincon; Alberto Pérez-López; David Morales-Alamo; Ismael Perez-Suarez; Pedro de Pablos-Velasco; Mario Perez-Valera; Sergio Perez-Regalado; Miriam Martinez-Canton; Miriam Gelabert-Rebato; Julian William Juan-Habib; Hans-Christer Holmberg; Jose A L Calbet
Journal:  Nutrients       Date:  2019-11-19       Impact factor: 5.717
  7 in total

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