| Literature DB >> 25673413 |
Adam E Locke1, Bratati Kahali2, Sonja I Berndt3, Anne E Justice4, Tune H Pers5,6,7,8, Felix R Day9, Corey Powell2, Sailaja Vedantam5,6, Martin L Buchkovich10, Jian Yang11,12, Damien C Croteau-Chonka10,13, Tonu Esko5,6,7,14, Tove Fall15,16,17, Teresa Ferreira18, Stefan Gustafsson16,17, Zoltán Kutalik19,20,21, Jian'an Luan9, Reedik Mägi14,18, Joshua C Randall18,22, Thomas W Winkler23, Andrew R Wood24, Tsegaselassie Workalemahu25, Jessica D Faul26, Jennifer A Smith27, Jing Hua Zhao9, Wei Zhao27, Jin Chen28, Rudolf Fehrmann29, Åsa K Hedman16,17,18, Juha Karjalainen29, Ellen M Schmidt30, Devin Absher31, Najaf Amin32, Denise Anderson33, Marian Beekman34,35, Jennifer L Bolton36, Jennifer L Bragg-Gresham1,37, Steven Buyske38,39, Ayse Demirkan32,40, Guohong Deng41,42,43, Georg B Ehret44,45, Bjarke Feenstra46, Mary F Feitosa47, Krista Fischer14, Anuj Goel18,48, Jian Gong49, Anne U Jackson1, Stavroula Kanoni50, Marcus E Kleber51,52, Kati Kristiansson53, Unhee Lim54, Vaneet Lotay55, Massimo Mangino56, Irene Mateo Leach57, Carolina Medina-Gomez58,59,60, Sarah E Medland61, Michael A Nalls62, Cameron D Palmer5,6, Dorota Pasko24, Sonali Pechlivanis63, Marjolein J Peters58,60, Inga Prokopenko18,64,65, Dmitry Shungin66,67,68, Alena Stančáková69, Rona J Strawbridge70, Yun Ju Sung71, Toshiko Tanaka72, Alexander Teumer73, Stella Trompet74,75, Sander W van der Laan76, Jessica van Setten77, Jana V Van Vliet-Ostaptchouk78, Zhaoming Wang3,79, Loïc Yengo80,81,82, Weihua Zhang41,83, Aaron Isaacs32,84, Eva Albrecht85, Johan Ärnlöv16,17,86, Gillian M Arscott87, Antony P Attwood88,89, Stefania Bandinelli90, Amy Barrett64, Isabelita N Bas91, Claire Bellis92,93, Amanda J Bennett64, Christian Berne94, Roza Blagieva95, Matthias Blüher96,97, Stefan Böhringer34,98, Lori L Bonnycastle99, Yvonne Böttcher96, Heather A Boyd46, Marcel Bruinenberg100, Ida H Caspersen101, Yii-Der Ida Chen102,103, Robert Clarke104, E Warwick Daw47, Anton J M de Craen75, Graciela Delgado51, Maria Dimitriou105, Alex S F Doney106, Niina Eklund53,107, Karol Estrada6,60,108, Elodie Eury80,81,82, Lasse Folkersen70, Ross M Fraser36, Melissa E Garcia109, Frank Geller46, Vilmantas Giedraitis110, Bruna Gigante111, Alan S Go112, Alain Golay113, Alison H Goodall114,115, Scott D Gordon61, Mathias Gorski23,116, Hans-Jörgen Grabe117,118, Harald Grallert85,119,120, Tanja B Grammer51, Jürgen Gräßler121, Henrik Grönberg15, Christopher J Groves64, Gaëlle Gusto122, Jeffrey Haessler49, Per Hall15, Toomas Haller14, Goran Hallmans123, Catharina A Hartman124, Maija Hassinen125, Caroline Hayward126, Nancy L Heard-Costa127,128, Quinta Helmer34,98,129, Christian Hengstenberg130,131, Oddgeir Holmen132, Jouke-Jan Hottenga133, Alan L James134,135, Janina M Jeff55, Åsa Johansson136, Jennifer Jolley88,89, Thorhildur Juliusdottir18, Leena Kinnunen53, Wolfgang Koenig52, Markku Koskenvuo137, Wolfgang Kratzer138, Jaana Laitinen139, Claudia Lamina140, Karin Leander111, Nanette R Lee91, Peter Lichtner141, Lars Lind142, Jaana Lindström53, Ken Sin Lo143, Stéphane Lobbens80,81,82, Roberto Lorbeer144, Yingchang Lu55,145, François Mach45, Patrik K E Magnusson15, Anubha Mahajan18, Wendy L McArdle146, Stela McLachlan36, Cristina Menni56, Sigrun Merger95, Evelin Mihailov14,147, Lili Milani14, Alireza Moayyeri56,148, Keri L Monda4,149, Mario A Morken99, Antonella Mulas150, Gabriele Müller151, Martina Müller-Nurasyid85,130,152,153, Arthur W Musk154, Ramaiah Nagaraja155, Markus M Nöthen156,157, Ilja M Nolte158, Stefan Pilz159,160, Nigel W Rayner18,22,64, Frida Renstrom66, Rainer Rettig161, Janina S Ried85, Stephan Ripke108,162, Neil R Robertson18,64, Lynda M Rose163, Serena Sanna150, Hubert Scharnagl164, Salome Scholtens100, Fredrick R Schumacher165, William R Scott41,83, Thomas Seufferlein138, Jianxin Shi166, Albert Vernon Smith167,168, Joanna Smolonska29,158, Alice V Stanton169, Valgerdur Steinthorsdottir170, Kathleen Stirrups22,50, Heather M Stringham1, Johan Sundström142, Morris A Swertz29, Amy J Swift99, Ann-Christine Syvänen16,171, Sian-Tsung Tan41,172, Bamidele O Tayo173, Barbara Thorand120,174, Gudmar Thorleifsson170, Jonathan P Tyrer175, Hae-Won Uh34,98, Liesbeth Vandenput176, Frank C Verhulst177, Sita H Vermeulen178,179, Niek Verweij57, Judith M Vonk158, Lindsay L Waite31, Helen R Warren180, Dawn Waterworth181, Michael N Weedon24, Lynne R Wilkens54, Christina Willenborg182,183, Tom Wilsgaard184, Mary K Wojczynski47, Andrew Wong185, Alan F Wright126, Qunyuan Zhang47, Eoin P Brennan186, Murim Choi187, Zari Dastani188, Alexander W Drong18, Per Eriksson70, Anders Franco-Cereceda189, Jesper R Gådin70, Ali G Gharavi190, Michael E Goddard191,192, Robert E Handsaker6,7, Jinyan Huang193,194, Fredrik Karpe64,195, Sekar Kathiresan6,196, Sarah Keildson18, Krzysztof Kiryluk190, Michiaki Kubo197, Jong-Young Lee198, Liming Liang193,199, Richard P Lifton200, Baoshan Ma193,201, Steven A McCarroll6,7,162, Amy J McKnight202, Josine L Min146, Miriam F Moffatt172, Grant W Montgomery61, Joanne M Murabito127,203, George Nicholson204,205, Dale R Nyholt61,206, Yukinori Okada207,208, John R B Perry18,24,56, Rajkumar Dorajoo209, Eva Reinmaa14, Rany M Salem5,6,7, Niina Sandholm210,211,212, Robert A Scott9, Lisette Stolk34,60, Atsushi Takahashi207, Toshihiro Tanaka208,213,214, Ferdinand M van 't Hooft70, Anna A E Vinkhuyzen11, Harm-Jan Westra29, Wei Zheng215, Krina T Zondervan18,216, Andrew C Heath217, Dominique Arveiler218, Stephan J L Bakker219, John Beilby87,220, Richard N Bergman221, John Blangero92, Pascal Bovet222,223, Harry Campbell36, Mark J Caulfield180, Giancarlo Cesana224, Aravinda Chakravarti44, Daniel I Chasman163,225, Peter S Chines99, Francis S Collins99, Dana C Crawford226,227, L Adrienne Cupples127,228, Daniele Cusi229,230, John Danesh231, Ulf de Faire111, Hester M den Ruijter76,232, Anna F Dominiczak233, Raimund Erbel234, Jeanette Erdmann182,183, Johan G Eriksson53,235,236, Martin Farrall18,48, Stephan B Felix237,238, Ele Ferrannini239,240, Jean Ferrières241, Ian Ford242, Nita G Forouhi9, Terrence Forrester243, Oscar H Franco58,59, Ron T Gansevoort219, Pablo V Gejman244, Christian Gieger85, Omri Gottesman55, Vilmundur Gudnason167,168, Ulf Gyllensten136, Alistair S Hall245, Tamara B Harris109, Andrew T Hattersley246, Andrew A Hicks247, Lucia A Hindorff248, Aroon D Hingorani249, Albert Hofman58,59, Georg Homuth73, G Kees Hovingh250, Steve E Humphries251, Steven C Hunt252, Elina Hyppönen253,254,255,256, Thomas Illig119,257, Kevin B Jacobs3,79, Marjo-Riitta Jarvelin83,258,259,260,261,261, Karl-Heinz Jöckel63, Berit Johansen101, Pekka Jousilahti53, J Wouter Jukema74,262,263, Antti M Jula53, Jaakko Kaprio53,107,137, John J P Kastelein250, Sirkka M Keinanen-Kiukaanniemi261,264, Lambertus A Kiemeney178,265, Paul Knekt53, Jaspal S Kooner41,172,266, Charles Kooperberg49, Peter Kovacs96,97, Aldi T Kraja47, Meena Kumari267,268, Johanna Kuusisto269, Timo A Lakka125,270,271, Claudia Langenberg9,267, Loic Le Marchand54, Terho Lehtimäki272, Valeriya Lyssenko273,274, Satu Männistö53, André Marette275,276, Tara C Matise39, Colin A McKenzie243, Barbara McKnight277, Frans L Moll278, Andrew D Morris106, Andrew P Morris14,18,279, Jeffrey C Murray280, Mari Nelis14, Claes Ohlsson176, Albertine J Oldehinkel124, Ken K Ong9,185, Pamela A F Madden217, Gerard Pasterkamp76, John F Peden281, Annette Peters119,130,174, Dirkje S Postma282, Peter P Pramstaller247,283, Jackie F Price36, Lu Qi13,25, Olli T Raitakari284,285, Tuomo Rankinen286, D C Rao47,71,217, Treva K Rice71,217, Paul M Ridker163,225, John D Rioux143,287, Marylyn D Ritchie288, Igor Rudan36,289, Veikko Salomaa53, Nilesh J Samani114,115, Jouko Saramies290, Mark A Sarzynski286, Heribert Schunkert130,131, Peter E H Schwarz121,291, Peter Sever292, Alan R Shuldiner293,294,295, Juha Sinisalo296, Ronald P Stolk158, Konstantin Strauch85,153, Anke Tönjes96,97, David-Alexandre Trégouët297,298,299, Angelo Tremblay300, Elena Tremoli301, Jarmo Virtamo53, Marie-Claude Vohl276,302, Uwe Völker73,238, Gérard Waeber303, Gonneke Willemsen133, Jacqueline C Witteman59, M Carola Zillikens58,60, Linda S Adair304, Philippe Amouyel305, Folkert W Asselbergs249,262,306, Themistocles L Assimes307, Murielle Bochud222,223, Bernhard O Boehm308,138, Eric Boerwinkle309, Stefan R Bornstein121, Erwin P Bottinger55, Claude Bouchard286, Stéphane Cauchi80,81,82, John C Chambers41,83,266, Stephen J Chanock3, Richard S Cooper173, Paul I W de Bakker77,310,311, George Dedoussis105, Luigi Ferrucci72, Paul W Franks25,66,67, Philippe Froguel65,80,81,82, Leif C Groop107,274, Christopher A Haiman165, Anders Hamsten70, Jennie Hui87,220,312, David J Hunter13,25,193, Kristian Hveem132, Robert C Kaplan313, Mika Kivimaki267, Diana Kuh185, Markku Laakso269, Yongmei Liu314, Nicholas G Martin61, Winfried März51,164,315, Mads Melbye307,316, Andres Metspalu14,147, Susanne Moebus63, Patricia B Munroe180, Inger Njølstad184, Ben A Oostra32,84,317, Colin N A Palmer106, Nancy L Pedersen15, Markus Perola14,53,107, Louis Pérusse276,300, Ulrike Peters49, Chris Power256, Thomas Quertermous307, Rainer Rauramaa125,271, Fernando Rivadeneira58,59,60, Timo E Saaristo318,319, Danish Saleheen231,320,321, Naveed Sattar322, Eric E Schadt323, David Schlessinger155, P Eline Slagboom34,35, Harold Snieder158, Tim D Spector56, Unnur Thorsteinsdottir170,324, Michael Stumvoll96,97, Jaakko Tuomilehto53,325,326,327, André G Uitterlinden58,59,60, Matti Uusitupa328,329, Pim van der Harst29,57,262, Mark Walker330, Henri Wallaschofski238,331, Nicholas J Wareham9, Hugh Watkins18,48, David R Weir26, H-Erich Wichmann332,333,334, James F Wilson36, Pieter Zanen335, Ingrid B Borecki47, Panos Deloukas22,50,336, Caroline S Fox127, Iris M Heid23,85, Jeffrey R O'Connell293,294, David P Strachan337, Kari Stefansson170,324, Cornelia M van Duijn32,58,59,84, Gonçalo R Abecasis1, Lude Franke29, Timothy M Frayling24, Mark I McCarthy18,64,338, Peter M Visscher11,12, André Scherag63,339, Cristen J Willer28,30,340, Michael Boehnke1, Karen L Mohlke10, Cecilia M Lindgren6,18, Jacques S Beckmann20,21,341, Inês Barroso22,342,343, Kari E North4,344, Erik Ingelsson16,17,18, Joel N Hirschhorn5,6,7, Ruth J F Loos9,55,145,345, Elizabeth K Speliotes2.
Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.Entities:
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Year: 2015 PMID： 25673413 PMCID： PMC4382211 DOI： 10.1038/nature14177
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962