Literature DB >> 25667249

Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis.

W Matthew Linam1, Mubbasheer Ahmed2, Jennifer R Cope3, Craig Chu2, Govinda S Visvesvara3, Alexandre J da Silva3, Yvonne Qvarnstrom3, Jerril Green2.   

Abstract

Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient's survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosine), and management of elevated intracranial pressure based on the principles of traumatic brain injury.
Copyright © 2015 by the American Academy of Pediatrics.

Entities:  

Keywords:  Naegleria fowleri; hypothermia; miltefosine; primary amebic meningoencephalitis

Mesh：

Substances：

Year:  2015        PMID： 25667249      PMCID： PMC4634363          DOI： 10.1542/peds.2014-2292

Source DB:  PubMed          Journal:  Pediatrics        ISSN： 0031-4005            Impact factor:   7.124


  23 in total

1.  Lack of effect of induction of hypothermia after acute brain injury.

Authors:  G L Clifton; E R Miller; S C Choi; H S Levin; S McCauley; K R Smith; J P Muizelaar; F C Wagner; D W Marion; T G Luerssen; R M Chesnut; M Schwartz
Journal:  N Engl J Med       Date:  2001-02-22       Impact factor: 91.245

2.  Immunohistochemical characterization of the initial stages of Naegleria fowleri meningoencephalitis in mice.

Authors:  Saul Rojas-Hernández; Adriana Jarillo-Luna; Marco Rodríguez-Monroy; Leticia Moreno-Fierros; Rafael Campos-Rodríguez
Journal:  Parasitol Res       Date:  2004-07-29       Impact factor: 2.289

3.  Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade.

Authors:  Lijun Xu; Midori A Yenari; Gary K Steinberg; Rona G Giffard
Journal:  J Cereb Blood Flow Metab       Date:  2002-01       Impact factor: 6.200

4.  Successful treatment of primary amebic meningoencephalitis.

Authors:  J S Seidel; P Harmatz; G S Visvesvara; A Cohen; J Edwards; J Turner
Journal:  N Engl J Med       Date:  1982-02-11       Impact factor: 91.245

5.  Hypothermia as an adjunctive treatment for severe bacterial meningitis.

Authors:  J E Irazuzta; R Pretzlaff; M Rowin; K Milam; F P Zemlan; B Zingarelli
Journal:  Brain Res       Date:  2000-10-20       Impact factor: 3.252

6.  Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.

Authors:  Shannon M Goswick; George M Brenner
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

7.  In vitro effect of antifungal drugs on pathogenic Naegleria spp.

Authors:  Supathra Tiewcharoen; Virach Junnu; Pisith Chinabut
Journal:  Southeast Asian J Trop Med Public Health       Date:  2002-03       Impact factor: 0.267

Review 8.  Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review.

Authors:  Lauralyn A McIntyre; Dean A Fergusson; Paul C Hébert; David Moher; James S Hutchison
Journal:  JAMA       Date:  2003-06-11       Impact factor: 56.272

9.  Notes from the field: primary amebic meningoencephalitis associated with ritual nasal rinsing--St. Thomas, U.S. Virgin islands, 2012.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2013-11-15       Impact factor: 17.586

10.  Investigational drug available directly from CDC for the treatment of infections with free-living amebae.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2013-08-23       Impact factor: 17.586
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  34 in total

1.  Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation.

Authors:  Jennifer R Cope; Jennifer Murphy; Amy Kahler; Daniel G Gorbett; Ibne Ali; Brandi Taylor; Lisa Corbitt; Shantanu Roy; Nicole Lee; Dawn Roellig; Scott Brewer; Vincent R Hill
Journal:  Clin Infect Dis       Date:  2018-02-01       Impact factor: 9.079

Review 2.  Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome.

Authors:  Timothy Yu Yee Ong; Naveed Ahmed Khan; Ruqaiyyah Siddiqui
Journal:  J Clin Microbiol       Date:  2017-04-12       Impact factor: 5.948

3.  Naegleria fowleri infections.

Authors:  W Matthew Linam; Jennifer R Cope
Journal:  Travel Med Infect Dis       Date:  2017-05-10       Impact factor: 6.211

4.  HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.

Authors:  Hye Jee Hahn; Ruben Abagyan; Larissa M Podust; Shantanu Roy; Ibne Karim M Ali; Anjan Debnath
Journal:  ACS Chem Neurosci       Date:  2020-09-19       Impact factor: 4.418

Review 5.  Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies.

Authors:  Kathleen E Sullivan; Hamid Bassiri; Ahmed A Bousfiha; Beatriz T Costa-Carvalho; Alexandra F Freeman; David Hagin; Yu L Lau; Michail S Lionakis; Ileana Moreira; Jorge A Pinto; M Isabel de Moraes-Pinto; Amit Rawat; Shereen M Reda; Saul Oswaldo Lugo Reyes; Mikko Seppänen; Mimi L K Tang
Journal:  J Clin Immunol       Date:  2017-08-07       Impact factor: 8.317

6.  A case of primary amebic meningoencephalitis caused by Naegleria fowleri in Bangladesh.

Authors:  Hossain M S Sazzad; Stephen P Luby; James Sejvar; Mahmudur Rahman; Emily S Gurley; Vincent Hill; Jennifer L Murphy; Shantanu Roy; Jennifer R Cope; Ibne K M Ali
Journal:  Parasitol Res       Date:  2019-11-16       Impact factor: 2.289

Review 7.  Naegleria fowleri: pathogenesis, diagnosis, and treatment options.

Authors:  Eddie Grace; Scott Asbill; Kris Virga
Journal:  Antimicrob Agents Chemother       Date:  2015-08-10       Impact factor: 5.191

Review 8.  Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5 Years?

Authors:  Jennifer R Cope; Ibne K Ali
Journal:  Curr Infect Dis Rep       Date:  2016-09       Impact factor: 3.725

9.  Activity of Auranofin against Multiple Genotypes of Naegleria fowleri and Its Synergistic Effect with Amphotericin B In Vitro.

Authors:  Jose Ignacio Escrig; Hye Jee Hahn; Anjan Debnath
Journal:  ACS Chem Neurosci       Date:  2020-05-26       Impact factor: 4.418

10.  Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case.

Authors:  Jennifer R Cope; Dennis A Conrad; Naiomi Cohen; Manuel Cotilla; Alexandre DaSilva; Jonathan Jackson; Govinda S Visvesvara
Journal:  Clin Infect Dis       Date:  2015-12-17       Impact factor: 9.079
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