Literature DB >> 26679626

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case.

Jennifer R Cope1, Dennis A Conrad2, Naiomi Cohen3, Manuel Cotilla3, Alexandre DaSilva4, Jonathan Jackson1, Govinda S Visvesvara1.   

Abstract

Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine. Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Entities:  

Keywords:  Naegleria fowleri; miltefosine; primary amebic meningoencephalitis

Mesh：

Substances：

Year:  2015        PMID： 26679626      PMCID： PMC4775347          DOI： 10.1093/cid/civ1021

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  10 in total

1.  Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement.

Authors:  Dalila Y Martínez; Carlos Seas; Francisco Bravo; Pedro Legua; Cesar Ramos; Alfonso M Cabello; Eduardo Gotuzzo
Journal:  Clin Infect Dis       Date:  2010-07-15       Impact factor: 9.079

2.  Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis.

Authors:  W Matthew Linam; Mubbasheer Ahmed; Jennifer R Cope; Craig Chu; Govinda S Visvesvara; Alexandre J da Silva; Yvonne Qvarnstrom; Jerril Green
Journal:  Pediatrics       Date:  2015-02-09       Impact factor: 7.124

3.  Primary amoebic meningoencephalitis.

Authors:  K Anderson; A Jamieson
Journal:  Lancet       Date:  1972-08-19       Impact factor: 79.321

4.  Successful treatment of primary amebic meningoencephalitis.

Authors:  J S Seidel; P Harmatz; G S Visvesvara; A Cohen; J Edwards; J Turner
Journal:  N Engl J Med       Date:  1982-02-11       Impact factor: 91.245

5.  Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin.

Authors:  Jesús Vargas-Zepeda; Alejandro V Gómez-Alcalá; José Alfonso Vásquez-Morales; Leonardo Licea-Amaya; Johan F De Jonckheere; Fernando Lares-Villa
Journal:  Arch Med Res       Date:  2005 Jan-Feb       Impact factor: 2.235

6.  Oral miltefosine for Indian visceral leishmaniasis.

Authors:  Shyam Sundar; T K Jha; C P Thakur; Juergen Engel; Herbert Sindermann; Christina Fischer; Klaus Junge; Anthony Bryceson; Jonathan Berman
Journal:  N Engl J Med       Date:  2002-11-28       Impact factor: 91.245

7.  The first association of a primary amebic meningoencephalitis death with culturable Naegleria fowleri in tap water from a US treated public drinking water system.

Authors:  Jennifer R Cope; Raoult C Ratard; Vincent R Hill; Theresa Sokol; Jonathan Jake Causey; Jonathan S Yoder; Gayatri Mirani; Bonnie Mull; Kimberly A Mukerjee; Jothikumar Narayanan; Meggie Doucet; Yvonne Qvarnstrom; Charla N Poole; Olugbenga A Akingbola; Jana M Ritter; Zhenggang Xiong; Alexandre J da Silva; Dawn Roellig; Russell B Van Dyke; Harlan Stern; Lihua Xiao; Michael J Beach
Journal:  Clin Infect Dis       Date:  2015-01-16       Impact factor: 9.079

8.  Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water.

Authors:  Jonathan S Yoder; Susanne Straif-Bourgeois; Sharon L Roy; Thomas A Moore; Govinda S Visvesvara; Raoult C Ratard; Vincent R Hill; Jon D Wilson; Andrea J Linscott; Ron Crager; Natalia A Kozak; Rama Sriram; Jothikumar Narayanan; Bonnie Mull; Amy M Kahler; Chandra Schneeberger; Alexandre J da Silva; Mahendra Poudel; Katherine L Baumgarten; Lihua Xiao; Michael J Beach
Journal:  Clin Infect Dis       Date:  2012-08-22       Impact factor: 9.079

9.  Notes from the field: primary amebic meningoencephalitis associated with ritual nasal rinsing--St. Thomas, U.S. Virgin islands, 2012.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2013-11-15       Impact factor: 17.586

10.  Investigational drug available directly from CDC for the treatment of infections with free-living amebae.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2013-08-23       Impact factor: 17.586
  10 in total
  17 in total

Review 1.  Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5 Years?

Authors:  Jennifer R Cope; Ibne K Ali
Journal:  Curr Infect Dis Rep       Date:  2016-09       Impact factor: 3.725

2.  NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri.

Authors:  Jong-Hyun Kim; Hae-Jin Sohn; Jong-Kyun Yoo; Heekyoung Kang; Gi-Sang Seong; Yong-Joon Chwae; Kyongmin Kim; Sun Park; Ho-Joon Shin
Journal:  Infect Immun       Date:  2016-08-19       Impact factor: 3.441

3.  Naegleria fowleri after 50 years: is it a neglected pathogen?

Authors:  Moisés Martínez-Castillo; Roberto Cárdenas-Zúñiga; Daniel Coronado-Velázquez; Anjan Debnath; Jesús Serrano-Luna; Mineko Shibayama
Journal:  J Med Microbiol       Date:  2016-07-04       Impact factor: 2.472

4.  Epidemiology and Clinical Characteristics of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri: A Global Review.

Authors:  Radhika Gharpure; John Bliton; Alexandra Goodman; Ibne Karim M Ali; Jonathan Yoder; Jennifer R Cope
Journal:  Clin Infect Dis       Date:  2021-07-01       Impact factor: 20.999

5.  Opportunistic free-living amoebal pathogens.

Authors:  Mohammad Ridwane Mungroo; Naveed Ahmed Khan; Sutherland Maciver; Ruqaiyyah Siddiqui
Journal:  Pathog Glob Health       Date:  2021-10-02       Impact factor: 3.735

6.  A Fatal Case of Primary Amoebic Meningoencephalitis from Recreational Waters.

Authors:  Edward Hamaty; Saif Faiek; Minesh Nandi; David Stidd; Manish Trivedi; Hari Kandukuri
Journal:  Case Rep Crit Care       Date:  2020-05-28

7.  A case of Naegleria fowleri related primary amoebic meningoencephalitis in China diagnosed by next-generation sequencing.

Authors:  Qiang Wang; Jianming Li; Jingkai Ji; Liuqing Yang; Li Chen; Rongrong Zhou; Yang Yang; Haixia Zheng; Jing Yuan; Liqiang Li; Yuhai Bi; George F Gao; Jinmin Ma; Yingxia Liu
Journal:  BMC Infect Dis       Date:  2018-07-28       Impact factor: 3.090

Review 8.  Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae.

Authors:  Alexandre Taravaud; Zineb Fechtali-Moute; Philippe M Loiseau; Sébastien Pomel
Journal:  Clin Transl Sci       Date:  2021-03-01       Impact factor: 4.689

9.  A case report: primary amoebic meningoencephalitis in a young Zambian adult.

Authors:  Mashina Chomba; Luchenga A Mucheleng'anga; Sombo Fwoloshi; Joseph Ngulube; Mable M Mutengo
Journal:  BMC Infect Dis       Date:  2017-08-01       Impact factor: 3.090

10.  Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri.

Authors:  Emily K Herman; Alex Greninger; Mark van der Giezen; Michael L Ginger; Inmaculada Ramirez-Macias; Haylea C Miller; Matthew J Morgan; Anastasios D Tsaousis; Katrina Velle; Romana Vargová; Kristína Záhonová; Sebastian Rodrigo Najle; Georgina MacIntyre; Norbert Muller; Mattias Wittwer; Denise C Zysset-Burri; Marek Eliáš; Claudio H Slamovits; Matthew T Weirauch; Lillian Fritz-Laylin; Francine Marciano-Cabral; Geoffrey J Puzon; Tom Walsh; Charles Chiu; Joel B Dacks
Journal:  BMC Biol       Date:  2021-07-22       Impact factor: 7.431
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