Junying Zhou1, Jihui Zhang2, Yun Li3, Lina Du3, Zhe Li3, Fei Lei3, Yun-Kwok Wing2, Clete A Kushida4, Dong Zhou3, Xiangdong Tang5. 1. Sleep Medicine Center, Mental Health Center, Department of Neurology, Translational Center, West China Hospital, Sichuan University, Chengdu, China; Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. 2. Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. 3. Sleep Medicine Center, Mental Health Center, Department of Neurology, Translational Center, West China Hospital, Sichuan University, Chengdu, China. 4. Sleep Medicine Center, Stanford University, CA, USA. 5. Sleep Medicine Center, Mental Health Center, Department of Neurology, Translational Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: 2372564613@qq.com.
Abstract
OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) has been considered a male-predominant parasomnia, and there is little comparative data on potential differences between males and females. Therefore, the aim of our study was to examine and characterize gender difference in RBD. METHODS: Ninety patients diagnosed with RBD were consecutively recruited from a sleep medicine clinic. All patients were assessed by a RBD questionnaire and overnight video polysomnography. Demographic, clinical data, presence of dreams and dream-enacting behaviors, sleep parameters and electromyographic (EMG) activity were compared for male and female patients with RBD. RESULTS: Females were significantly younger than males, both in the mean age of RBD onset (45.3 ± 19.3 vs. 56.2 ± 14.1; p = 0.027) and the mean age at diagnosis (50.4 ± 18.2 vs. 61.1 ± 14.1; p = 0.022). Secondary RBD was 21% in males and 44% in females (p = 0.021). Antidepressant use was more common among females (22%) than males (2%; p = 0.003). There was no significant gender difference in dream content (eg, violent and frightening dreams) of RBD patients. However, females had less dream-enacting behaviors, especially in movement related dreams and falling out of bed. Interestingly, no significant difference was found in the quantification of EMG activity during REM sleep between male and female patients. CONCLUSIONS: We found significant gender differences in demographics, associated comorbidities, and dream-related behaviors in patients with RBD. Female RBD patients reported significantly less behavior during dreams, but there was no significant gender difference in EMG activity during REM sleep.
OBJECTIVE:Rapid eye movement (REM) sleep behavior disorder (RBD) has been considered a male-predominant parasomnia, and there is little comparative data on potential differences between males and females. Therefore, the aim of our study was to examine and characterize gender difference in RBD. METHODS: Ninety patients diagnosed with RBD were consecutively recruited from a sleep medicine clinic. All patients were assessed by a RBD questionnaire and overnight video polysomnography. Demographic, clinical data, presence of dreams and dream-enacting behaviors, sleep parameters and electromyographic (EMG) activity were compared for male and female patients with RBD. RESULTS: Females were significantly younger than males, both in the mean age of RBD onset (45.3 ± 19.3 vs. 56.2 ± 14.1; p = 0.027) and the mean age at diagnosis (50.4 ± 18.2 vs. 61.1 ± 14.1; p = 0.022). Secondary RBD was 21% in males and 44% in females (p = 0.021). Antidepressant use was more common among females (22%) than males (2%; p = 0.003). There was no significant gender difference in dream content (eg, violent and frightening dreams) of RBD patients. However, females had less dream-enacting behaviors, especially in movement related dreams and falling out of bed. Interestingly, no significant difference was found in the quantification of EMG activity during REM sleep between male and female patients. CONCLUSIONS: We found significant gender differences in demographics, associated comorbidities, and dream-related behaviors in patients with RBD. Female RBD patients reported significantly less behavior during dreams, but there was no significant gender difference in EMG activity during REM sleep.
Authors: Tanis J Ferman; Naoya Aoki; Bradley F Boeve; Jeremiah A Aakre; Kejal Kantarci; Jonathan Graff-Radford; Joseph E Parisi; Jay A Van Gerpen; Neill R Graff-Radford; Ryan J Uitti; Otto Pedraza; Melissa E Murray; Zbigniew K Wszolek; R Ross Reichard; Julie A Fields; Owen A Ross; David S Knopman; Ronald C Petersen; Dennis W Dickson Journal: Neurology Date: 2020-06-19 Impact factor: 9.910
Authors: Lilian Calderón-Garcidueñas; Ravi Philip Rajkumar; Elijah W Stommel; Randy Kulesza; Yusra Mansour; Adriana Rico-Villanueva; Jorge Orlando Flores-Vázquez; Rafael Brito-Aguilar; Silvia Ramírez-Sánchez; Griselda García-Alonso; Diana A Chávez-Franco; Samuel C Luévano-Castro; Edgar García-Rojas; Paula Revueltas-Ficachi; Rodolfo Villarreal-Ríos; Partha S Mukherjee Journal: Int J Environ Res Public Health Date: 2021-06-22 Impact factor: 3.390