Literature DB >> 25624315

Fruit flies in biomedical research.

Michael F Wangler1, Shinya Yamamoto2, Hugo J Bellen3.   

Abstract

Many scientists complain that the current funding situation is dire. Indeed, there has been an overall decline in support in funding for research from the National Institutes of Health and the National Science Foundation. Within the Drosophila field, some of us question how long this funding crunch will last as it demotivates principal investigators and perhaps more importantly affects the long-term career choice of many young scientists. Yet numerous very interesting biological processes and avenues remain to be investigated in Drosophila, and probing questions can be answered fast and efficiently in flies to reveal new biological phenomena. Moreover, Drosophila is an excellent model organism for studies that have translational impact for genetic disease and for other medical implications such as vector-borne illnesses. We would like to promote a better collaboration between Drosophila geneticists/biologists and human geneticists/bioinformaticians/clinicians, as it would benefit both fields and significantly impact the research on human diseases.
Copyright © 2015 by the Genetics Society of America.

Entities:  

Keywords:  Drosophila; GWAS; collaboration; functional genomics; funding; genetic disease; human; public health; whole-exome sequencing

Mesh:

Year:  2015        PMID: 25624315      PMCID: PMC4349060          DOI: 10.1534/genetics.114.171785

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  154 in total

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Review 2.  A fruitfly's guide to keeping the brain wired.

Authors:  Maarten Leyssen; Bassem A Hassan
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3.  Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

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Journal:  Cell       Date:  2000-07-07       Impact factor: 41.582

4.  Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome.

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Journal:  Curr Biol       Date:  2012-05-31       Impact factor: 10.834

5.  Neurite arborization and mosaic spacing in the mouse retina require DSCAM.

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6.  A timely arrival for genomic medicine.

Authors:  Alan N Mayer; David P Dimmock; Marjorie J Arca; David P Bick; James W Verbsky; Elizabeth A Worthey; Howard J Jacob; David A Margolis
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7.  Identification and characterization of insect-specific proteins by genome data analysis.

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Journal:  BMC Genomics       Date:  2007-04-04       Impact factor: 3.969

8.  Genic intolerance to functional variation and the interpretation of personal genomes.

Authors:  Slavé Petrovski; Quanli Wang; Erin L Heinzen; Andrew S Allen; David B Goldstein
Journal:  PLoS Genet       Date:  2013-08-22       Impact factor: 5.917

9.  FlyBase 102--advanced approaches to interrogating FlyBase.

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10.  Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster.

Authors:  Koen J T Venken; Joseph W Carlson; Karen L Schulze; Hongling Pan; Yuchun He; Rebecca Spokony; Kenneth H Wan; Maxim Koriabine; Pieter J de Jong; Kevin P White; Hugo J Bellen; Roger A Hoskins
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  65 in total

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Review 2.  Model organism data evolving in support of translational medicine.

Authors:  Douglas G Howe; Judith A Blake; Yvonne M Bradford; Carol J Bult; Brian R Calvi; Stacia R Engel; James A Kadin; Thomas C Kaufman; Ranjana Kishore; Stanley J F Laulederkind; Suzanna E Lewis; Sierra A T Moxon; Joel E Richardson; Cynthia Smith
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3.  Dietary rescue of altered metabolism gene reveals unexpected Drosophila mating cues.

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Journal:  J Lipid Res       Date:  2016-01-11       Impact factor: 5.922

Review 4.  Reverse-engineering organogenesis through feedback loops between model systems.

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Journal:  Curr Opin Biotechnol       Date:  2017-12-21       Impact factor: 9.740

5.  An Unbiased Drug Screen for Seizure Suppressors in Duplication 15q Syndrome Reveals 5-HT1A and Dopamine Pathway Activation as Potential Therapies.

Authors:  Bidisha Roy; Jungsoo Han; Kevin A Hope; Tracy L Peters; Glen Palmer; Lawrence T Reiter
Journal:  Biol Psychiatry       Date:  2020-04-13       Impact factor: 13.382

6.  Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Authors:  Priya S Shah; Nichole Link; Gwendolyn M Jang; Phillip P Sharp; Tongtong Zhu; Danielle L Swaney; Jeffrey R Johnson; John Von Dollen; Holly R Ramage; Laura Satkamp; Billy Newton; Ruth Hüttenhain; Marine J Petit; Tierney Baum; Amanda Everitt; Orly Laufman; Michel Tassetto; Michael Shales; Erica Stevenson; Gabriel N Iglesias; Leila Shokat; Shashank Tripathi; Vinod Balasubramaniam; Laurence G Webb; Sebastian Aguirre; A Jeremy Willsey; Adolfo Garcia-Sastre; Katherine S Pollard; Sara Cherry; Andrea V Gamarnik; Ivan Marazzi; Jack Taunton; Ana Fernandez-Sesma; Hugo J Bellen; Raul Andino; Nevan J Krogan
Journal:  Cell       Date:  2018-12-13       Impact factor: 41.582

7.  Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides.

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Journal:  Insect Biochem Mol Biol       Date:  2016-12-21       Impact factor: 4.714

Review 8.  Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.

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Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

9.  Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway.

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Review 10.  Studying polyglutamine diseases in Drosophila.

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Journal:  Exp Neurol       Date:  2015-08-06       Impact factor: 5.330

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