Literature DB >> 17203102

A fruitfly's guide to keeping the brain wired.

Maarten Leyssen1, Bassem A Hassan.   

Abstract

The behaviour of all animals is governed by the connectivity of neural circuits in the brain. Neurodevelopmental and neurodegenerative diseases, as well as traumatic injuries to the nervous system, can alter or disrupt the normal connectivity of the brain and result in disability. In this review, we highlight the contributions of the genetic model organism Drosophila melanogaster to our understanding of neural connectivity in health and disease. In this context we also discuss the research areas in which we believe the fruitfly is likely to be a useful model system in the future.

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Year:  2007        PMID： 17203102      PMCID： PMC1796755          DOI： 10.1038/sj.embor.7400869

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  39 in total

1.  Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.

Authors:  A Kamal; G B Stokin; Z Yang; C H Xia; L S Goldstein
Journal:  Neuron       Date:  2000-11       Impact factor: 17.173

Review 2.  The circadian timekeeping system of Drosophila.

Authors:  Paul E Hardin
Journal:  Curr Biol       Date:  2005-09-06       Impact factor: 10.834

3.  APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.

Authors:  Anne Rovelet-Lecrux; Didier Hannequin; Gregory Raux; Nathalie Le Meur; Annie Laquerrière; Anne Vital; Cécile Dumanchin; Sébastien Feuillette; Alexis Brice; Martine Vercelletto; Frédéric Dubas; Thierry Frebourg; Dominique Campion
Journal:  Nat Genet       Date:  2005-12-20       Impact factor: 38.330

Review 4.  Axon retraction and degeneration in development and disease.

Authors:  Liqun Luo; Dennis D M O'Leary
Journal:  Annu Rev Neurosci       Date:  2005       Impact factor: 12.449

5.  The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.

Authors:  Simon P Reeve; Laura Bassetto; Ginka K Genova; Yelena Kleyner; Maarten Leyssen; F Rob Jackson; Bassem A Hassan
Journal:  Curr Biol       Date:  2005-06-21       Impact factor: 10.834

Review 6.  Come FLY with us: toward understanding fragile X syndrome.

Authors:  D C Zarnescu; G Shan; S T Warren; P Jin
Journal:  Genes Brain Behav       Date:  2005-08       Impact factor: 3.449

Review 7.  Drosophila as a model for human neurodegenerative disease.

Authors:  Julide Bilen; Nancy M Bonini
Journal:  Annu Rev Genet       Date:  2005       Impact factor: 16.830

8.  Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain.

Authors:  Maarten Leyssen; Derya Ayaz; Sébastien S Hébert; Simon Reeve; Bart De Strooper; Bassem A Hassan
Journal:  EMBO J       Date:  2005-07-28       Impact factor: 11.598

9.  Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.

Authors:  Sean M J McBride; Catherine H Choi; Yan Wang; David Liebelt; Evan Braunstein; David Ferreiro; Amita Sehgal; Kathleen K Siwicki; Thomas C Dockendorff; Hanh T Nguyen; Thomas V McDonald; Thomas A Jongens
Journal:  Neuron       Date:  2005-03-03       Impact factor: 17.173

Review 10.  Early-life risk factors for Alzheimer disease.

Authors:  Amy R Borenstein; Cathleen I Copenhaver; James A Mortimer
Journal:  Alzheimer Dis Assoc Disord       Date:  2006 Jan-Mar       Impact factor: 2.703
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  8 in total

1.  Fruit flies in biomedical research.

Authors:  Michael F Wangler; Shinya Yamamoto; Hugo J Bellen
Journal:  Genetics       Date:  2015-01-26       Impact factor: 4.562

2.  Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

Authors:  Burkhard Jakob; Gaga Kochlamazashvili; Maria Jäpel; Aziz Gauhar; Hans H Bock; Tanja Maritzen; Volker Haucke
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-08       Impact factor: 11.205

Review 3.  The role of the actin cytoskeleton in regulating Drosophila behavior.

Authors:  Shamsideen A Ojelade; Summer F Acevedo; Adrian Rothenfluh
Journal:  Rev Neurosci       Date:  2013       Impact factor: 4.353

Review 4.  Drosophila as a model to explore secondary injury cascades after traumatic brain injury.

Authors:  Lori M Buhlman; Gokul Krishna; T Bucky Jones; Theresa Currier Thomas
Journal:  Biomed Pharmacother       Date:  2021-08-27       Impact factor: 7.419

Review 5.  Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.

Authors:  Judith A Tello; Haley E Williams; Robert M Eppler; Michelle L Steinhilb; May Khanna
Journal:  Front Mol Neurosci       Date:  2022-04-19       Impact factor: 6.261

6.  Axonal injury and regeneration in the adult brain of Drosophila.

Authors:  Derya Ayaz; Maarten Leyssen; Marta Koch; Jiekun Yan; Mohammed Srahna; Vasu Sheeba; Keri J Fogle; Todd C Holmes; Bassem A Hassan
Journal:  J Neurosci       Date:  2008-06-04       Impact factor: 6.167

Review 7.  The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.

Authors:  Caroline B Palavicino-Maggio; Saheli Sengupta
Journal:  Front Behav Neurosci       Date:  2022-04-18       Impact factor: 3.617

8.  Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima.

Authors:  José E San Miguel-Ruiz; Angel R Maldonado-Soto; José E García-Arrarás
Journal:  BMC Dev Biol       Date:  2009-01-06       Impact factor: 1.978
  8 in total

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