Ernesto Di Cesare1, Antonio Gennarelli2, Alessandra Di Sibio2, Valentina Felli2, Alessandra Splendiani2, Giovanni Luca Gravina3, Carlo Masciocchi2. 1. Department of Biotechnological and Applied Clinical Sciences, Division of Radiotherapy, Laboratory of Radiobiology, University of L'Aquila, Italy. Electronic address: ernesto.dicesare@cc.univaq.it. 2. Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, Laboratory of Radiobiology, University of L'Aquila, Italy. 3. Department of Biotechnological and Applied Clinical Sciences, Division of Radiotherapy, Laboratory of Radiobiology, University of L'Aquila, Italy.
Abstract
OBJECTIVES: To evaluate image quality and radiation dose of single heartbeat 640-slice coronary CT angiography (CCTA) in patients with chronic Atrial Fibrillation (cAF) in comparison with subjects in normal sinus rhythm. METHODS: A cohort of 71 patients with cAF was matched with 71 subjects in normal sinus rhythm (NSR) and HR≤65 bpm using a matched by propensity analysis. All subjects underwent a single heartbeat CCTA with prospective gating. In subjects with cAF, we manually established the acquisition of data only from a single heartbeat. Mean effective dose and image quality, with both objective and subjective measures, were assessed. RESULTS: 96.4% of all segments in the cAF group had diagnostic image quality. The rate of subjects with at least one non-diagnostic segment was 14% and 2.8% (p=0.031) in the cAF and NRS groups, respectively. In the cAF group, the percentage of patients with at least one non-diagnostic segment for acquisition HR≤72 was 1.8% (1/55), and it did not significantly differ from the NSR group (2.8%; 2/71) (p=1.0). Objective quality parameters did not show a statistically significant difference between the two groups. The mean effective dose was 4.24±1.24 mSv in the cAF group and 2.67±0.5 mSv in the sinus rhythm group (p<0.0001) with an increase by 59% in the cAF group with respect to the SNR group. CONCLUSIONS: A single heartbeat acquisition protocol with a 640-slice prospectively ECG-triggered CT angiography may be feasible in patients with cAF and HR below 72 bpm at the CT acquisition, although mean effective dose of this protocol in cAF group was 59% higher than in sinus rhythm one. In patients with cAF and a heart rate higher than 72 bpm, CCTA tends to have more movement-associated artefacts.
OBJECTIVES: To evaluate image quality and radiation dose of single heartbeat 640-slice coronary CT angiography (CCTA) in patients with chronic Atrial Fibrillation (cAF) in comparison with subjects in normal sinus rhythm. METHODS: A cohort of 71 patients with cAF was matched with 71 subjects in normal sinus rhythm (NSR) and HR≤65 bpm using a matched by propensity analysis. All subjects underwent a single heartbeat CCTA with prospective gating. In subjects with cAF, we manually established the acquisition of data only from a single heartbeat. Mean effective dose and image quality, with both objective and subjective measures, were assessed. RESULTS: 96.4% of all segments in the cAF group had diagnostic image quality. The rate of subjects with at least one non-diagnostic segment was 14% and 2.8% (p=0.031) in the cAF and NRS groups, respectively. In the cAF group, the percentage of patients with at least one non-diagnostic segment for acquisition HR≤72 was 1.8% (1/55), and it did not significantly differ from the NSR group (2.8%; 2/71) (p=1.0). Objective quality parameters did not show a statistically significant difference between the two groups. The mean effective dose was 4.24±1.24 mSv in the cAF group and 2.67±0.5 mSv in the sinus rhythm group (p<0.0001) with an increase by 59% in the cAF group with respect to the SNR group. CONCLUSIONS: A single heartbeat acquisition protocol with a 640-slice prospectively ECG-triggered CT angiography may be feasible in patients with cAF and HR below 72 bpm at the CT acquisition, although mean effective dose of this protocol in cAF group was 59% higher than in sinus rhythm one. In patients with cAF and a heart rate higher than 72 bpm, CCTA tends to have more movement-associated artefacts.
Authors: A Splendiani; F D'Orazio; L Patriarca; F Arrigoni; F Caranci; P Fonio; L Brunese; A Barile; E Di Cesare; C Masciocchi Journal: Musculoskelet Surg Date: 2017-02-06
Authors: Anna Matveeva; Rainer R Schmitt; Karoline Edtinger; Matthias Wagner; Sebastian Kerber; Thomas Deneke; Michael Uder; Sebastian Barth Journal: Eur Radiol Date: 2018-02-09 Impact factor: 5.315
Authors: Ernesto Di Cesare; Antonio Gennarelli; Alessandra Di Sibio; Valentina Felli; Marco Perri; Alessandra Splendiani; Giovanni Luca Gravina; Antonio Barile; Carlo Masciocchi Journal: Radiol Med Date: 2016-05-12 Impact factor: 3.469
Authors: Francesco Secchi; Marco Alì; Elena Faggiano; Paola Maria Cannaò; Marco Fedele; Silvia Tresoldi; Giovanni Di Leo; Ferdinando Auricchio; Francesco Sardanelli Journal: Eur Heart J Suppl Date: 2016-04-29 Impact factor: 1.803
Authors: Filippo Cademartiri; Ernesto Di Cesare; Marco Francone; Giovanni Ballerini; Guido Ligabue; Erica Maffei; Andrea Romagnoli; Giovanni Maria Argiolas; Vincenzo Russo; Vitaliano Buffa; Riccardo Marano; Maria Guzzetta; Manuel Belgrano; Iacopo Carbone; Luca Macarini; Claudia Borghi; Paolo Di Renzi; Vicenzo Barile; Lucia Patriarca Journal: Radiol Med Date: 2015-02-21 Impact factor: 3.469
Authors: Ernesto Di Cesare; Scipione Carerj; Anna Palmisano; Maria Ludovica Carerj; Federica Catapano; Davide Vignale; Annamaria Di Cesare; Gianluca Milanese; Nicola Sverzellati; Marco Francone; Antonio Esposito Journal: Radiol Med Date: 2020-07-16 Impact factor: 3.469
Authors: Alice La Marra; Simone Quarchioni; Fabiana Ferrari; Giovanni Luca Gravina; Antonio Barile; Lorenzo Maria Gregori; Ernesto Di Cesare; Alessandra Splendiani Journal: PLoS One Date: 2016-09-23 Impact factor: 3.240