Shasha Yang1, Chengguo Zuo1, Hui Xiao1, Lan Mi1, Guangwei Luo1, Xiaoyu Xu1, Xing Liu2. 1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, 510060, China. 2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, 510060, China. liuxing@mail.sysu.edu.cn.
Abstract
PURPOSE: To evaluate the changes of the photoreceptor layer (PRL) thickness with spectral domain optical coherence tomography (SD-OCT) and the retinal function by mfERG, as well as the correlation of morphology and function parameters in subjects with early and intermediate age-related macular degeneration (AMD). METHODS: Subjects with clinical diagnosis of early or intermediate AMD and age-matched healthy subjects were recruited prospectively in this study. Color fundus photography, SD-OCT, and mfERG were conducted. Retinal photoreceptor thickness was measured, and first-order kernel responses were recorded. The differences between AMD group and control group were compared, and the correlations between macular photoreceptor thickness and the mfERG were analyzed. RESULTS: PRL thickness (μm) in four areas including foveola and 0.5, 1.5, and 3 mm away from foveola was 192.48 ± 17.37, 163.73 ± 12.95, 130.93 ± 9.20, and 108.78 ± 7.81, respectively, in normal eyes, whereas in AMD group, they were 158.61 ± 45.25, 138.91 ± 20.92, 118.91 ± 12.85, and 95.00 ± 9.64, respectively (P < 0.001). The mean amplitude response densities of AMD patients decreased significantly compared to the control group in ring 1-6 (P < 0.001). The mean mfERG N1 and P1 latency of AMD patients prolonged compared to the control group, except the ring 1 (P = 0.588 and P = 0.084). The macular PRL thickness was significantly associated with the mfERGN1 and P1 amplitude density in ring 1-4 (r = 0.338-0.533, P < 0.01). CONCLUSIONS: PRL thickness decreases are in accordance with the deterioration of retinal electrophysiological activity. The retinal PRL thickness is important parameter to assess of early and intermediate AMD severity.
PURPOSE: To evaluate the changes of the photoreceptor layer (PRL) thickness with spectral domain optical coherence tomography (SD-OCT) and the retinal function by mfERG, as well as the correlation of morphology and function parameters in subjects with early and intermediate age-related macular degeneration (AMD). METHODS: Subjects with clinical diagnosis of early or intermediate AMD and age-matched healthy subjects were recruited prospectively in this study. Color fundus photography, SD-OCT, and mfERG were conducted. Retinal photoreceptor thickness was measured, and first-order kernel responses were recorded. The differences between AMD group and control group were compared, and the correlations between macular photoreceptor thickness and the mfERG were analyzed. RESULTS: PRL thickness (μm) in four areas including foveola and 0.5, 1.5, and 3 mm away from foveola was 192.48 ± 17.37, 163.73 ± 12.95, 130.93 ± 9.20, and 108.78 ± 7.81, respectively, in normal eyes, whereas in AMD group, they were 158.61 ± 45.25, 138.91 ± 20.92, 118.91 ± 12.85, and 95.00 ± 9.64, respectively (P < 0.001). The mean amplitude response densities of AMDpatients decreased significantly compared to the control group in ring 1-6 (P < 0.001). The mean mfERG N1 and P1 latency of AMDpatients prolonged compared to the control group, except the ring 1 (P = 0.588 and P = 0.084). The macular PRL thickness was significantly associated with the mfERGN1 and P1 amplitude density in ring 1-4 (r = 0.338-0.533, P < 0.01). CONCLUSIONS: PRL thickness decreases are in accordance with the deterioration of retinal electrophysiological activity. The retinal PRL thickness is important parameter to assess of early and intermediate AMD severity.
Authors: Pratul P Srinivasan; Leo A Kim; Priyatham S Mettu; Scott W Cousins; Grant M Comer; Joseph A Izatt; Sina Farsiu Journal: Biomed Opt Express Date: 2014-09-12 Impact factor: 3.732
Authors: Patrick T Johnson; Geoffrey P Lewis; Kevin C Talaga; Meghan N Brown; Peter J Kappel; Steven K Fisher; Don H Anderson; Lincoln V Johnson Journal: Invest Ophthalmol Vis Sci Date: 2003-10 Impact factor: 4.799
Authors: Geoffrey K Broadhead; John R Grigg; Peter McCluskey; Thomas Hong; Timothy E Schlub; Andrew A Chang Journal: Graefes Arch Clin Exp Ophthalmol Date: 2018-10-20 Impact factor: 3.117
Authors: Hernán H Dieguez; Horacio E Romeo; María F González Fleitas; Marcos L Aranda; Georgia A Milne; Ruth E Rosenstein; Damián Dorfman Journal: Dis Model Mech Date: 2018-02-07 Impact factor: 5.758