Implication for health policy/practice/research/medical education:
Clinical care should therefore focus on increasing dietary magnesium intake or magnesium supplementation to improve metabolic control and prevent dyslipidemia in 2 diabetes mellituspatients.Magnesium (Mg) is the fourth most plentiful mineral and encountered as the second most abundant intracellular divalent cation and has been accepted as a cofactor for >300 metabolic reactions in in humans (1). Around 50% of this element is in the bone tissue, 50% is in the tissues and organs, and 1% is in the blood (1,2). Mg is a significant cofactor in a number of key enzymatic reactions and seems to play a vital role in glucose metabolism and insulin homeostasis (2-4). Recently, various evidences suggesting a relationship of Mg deficiency and type 2 diabetes mellitus (T2DM). T2DM is a main global public health problem in the world and is rising in aging populations (4,5). In the study conducted by Dasgupta et al. on 150 T2DM patients, low Mg level was documented in 11.33% of patients. They interpreted that hypomagnesemia in diabetes mellitus was correlated with poorer diabetic control, nephropathy, retinopathy and foot ulcers (6). Likewise, Baig et al. conducted an investigation on 60 T2DM patients between 40 and 70 years of age. They detected that the mean serum Mg value was significantly low in T2DM patients without and with complications when compared with control group. Additionally, they showed that serum Mg value in cases with diabetic complications was significantly lower than those without complications (7). We also previously conducted a study to test the association of serum lipids with serum Mg in T2DM patients in 2008. In this study, on 122 T2DM patients, we found a significant inverse associations of serum Mg value with serum cholesterol and low-density lipoprotein cholesterol (LDL-C) (8). Recently, Kocot et al. carried-out a study on 54 T2DM. They found low serum value of Mg in diabetic individuals in comparison to healthy participants. They also detected a weak negative correlation between plasma magnesium level and total cholesterol and also between plasma Mg and serum triglyceride in diabeticpatients (9). The result of this study was in accord with our previous results. More recently Mishra et al. examined 45 known T2DM patients. They observed significant negative association of serum Mg level with triglyceride and very low-density lipoprotein cholesterol level and positive association of Mg with serum high-density lipoprotein cholesterol too (10). The association of hypomagnesemia and insulin resistance in diabetespatients has been documented previously. Accordingly in the study of 219 T2DM patients (11-13). Rasheed et al. observed serum Mg had significantly positive association with serum high-density lipoprotein cholesterol while total cholesterol and very low-density lipoprotein cholesterol was negatively correlated, though non-significantly, with serum Mg (14). Moreover, a study on 550 diabeticpatients, revealed serum Mg, significant negative correlation with glomerular filtration rate (15).
Conclusion
Clinical care should therefore focus on increasing dietary Mg intake or Mg supplementation to improve metabolic control and prevent dyslipidemia in T2DM patients.
Author’s contribution
HN is the single author of the paper.
Conflict of interests
The author declare that there were no conflicts of interest.
Ethical considerations
Ethical issues (including plagiarism, data fabrication, double publication) have been completely observed by the author.