Hamid Nasri1, Hamid-Reza Baradaran. 1. Shahrekord University of Medical Sciences, Hajar Medical, Educational and Therapeutic Center, Hemodialysis Section, Shahrekord, Iran. hamidnasri@yahoo.com
Abstract
AIM: To investigate whether and how serum Magnesium (Mg) concentrations influence the serum lipids in diabetes mellitus (DM) patients. The cross-sectional study was conducted on diabetic mellitus (DM) patients with various kidney functions not yet on dialysis. PATIENTS AND METHODS: Serum lipoprotein(a), glycosilated hemoglobin (HbA1c), serum magnesium (Mg), serum creatinine (creat), serum lipids consisting of triglycerids (Tg), cholesterol (Chol), high-density lipoprotein (HDL) were measured. RESULTS: Study patients included 122 patients (82F, 40M). The mean patients' age was 63 (+/- 10) years. The mean length of time they were diabetic was 7.4 (+/- 5.8) years (median: 6 years). The mean serum Mg was 2 (+/- 0.4) mg/dl (median: 1.99 mg/dl). The mean creatinine clearance was 64 (+/- 24) cc/min (median: 64 cc/min). In this study significant inverse correlations of serum Mg with serum cholesterol and LDL as well as nonsignificant correlations of serum Mg with serum Lp(a), HDL, Tg and with serum HgbA1c were seen. More over a significant inverse correlation of serum Mg with ages of the patients and a significant positive correlation of serum Mg with serum creatinine were seen too. CONCLUSIONS: It seems that in diabetic patients, kidney function is a key role in the regulation of serum Lp(a) levels instead of other factors like serum Mg level. Our finding further supports the importance of Mg supplementation in diabetes mellitus patients. In our study no significant correlation between serum Mg with serum HDL and Tg were found, which needs further investigation (Tab. 1, Fig. 4, Ref. 53).
AIM: To investigate whether and how serum Magnesium (Mg) concentrations influence the serum lipids in diabetes mellitus (DM) patients. The cross-sectional study was conducted on diabetic mellitus (DM) patients with various kidney functions not yet on dialysis. PATIENTS AND METHODS: Serum lipoprotein(a), glycosilated hemoglobin (HbA1c), serum magnesium (Mg), serum creatinine (creat), serum lipids consisting of triglycerids (Tg), cholesterol (Chol), high-density lipoprotein (HDL) were measured. RESULTS: Study patients included 122 patients (82F, 40M). The mean patients' age was 63 (+/- 10) years. The mean length of time they were diabetic was 7.4 (+/- 5.8) years (median: 6 years). The mean serum Mg was 2 (+/- 0.4) mg/dl (median: 1.99 mg/dl). The mean creatinine clearance was 64 (+/- 24) cc/min (median: 64 cc/min). In this study significant inverse correlations of serum Mg with serum cholesterol and LDL as well as nonsignificant correlations of serum Mg with serum Lp(a), HDL, Tg and with serum HgbA1c were seen. More over a significant inverse correlation of serum Mg with ages of the patients and a significant positive correlation of serum Mg with serum creatinine were seen too. CONCLUSIONS: It seems that in diabeticpatients, kidney function is a key role in the regulation of serum Lp(a) levels instead of other factors like serum Mg level. Our finding further supports the importance of Mg supplementation in diabetes mellituspatients. In our study no significant correlation between serum Mg with serum HDL and Tg were found, which needs further investigation (Tab. 1, Fig. 4, Ref. 53).
Authors: Gopal Niranjan; A R Srinivasan; K Srikanth; Gowda Pruthu; R Reeta; Ramasamy Ramesh; Rajendiran Anitha; V Mohana Valli Journal: Indian J Clin Biochem Date: 2018-05-03
Authors: Iwona Rotter; Danuta Kosik-Bogacka; Barbara Dołęgowska; Krzysztof Safranow; Anna Lubkowska; Maria Laszczyńska Journal: Int J Environ Res Public Health Date: 2015-04-10 Impact factor: 3.390