Literature DB >> 25610733

M1 and M2: there is no "good" and "bad"-How macrophages promote malignancy-associated features in tumorigenesis.

Ole Helm1, Janka Held-Feindt2, Heiner Schäfer3, Susanne Sebens1.   

Abstract

We recently identified tumor-associated macrophages from pancreatic ductal adenocarcinoma sharing pro- and anti-inflammatory characteristics. Already in residence in the setting of chronic pancreatitis, local macrophages confer malignancy-associated features to premalignant pancreatic ductal epithelial cells by both promoting and inhibiting inflammation, either of which can foster malignant conversion. Our findings support the concept that contrasting modes of inflammation can promote tumorigenesis.

Entities:  

Keywords:  epithelial-mesenchymal transition; inflammation-associated tumorigenesis; macrophages; pancreatic cancer; tumor stroma

Year:  2014        PMID： 25610733      PMCID： PMC4292215          DOI： 10.4161/21624011.2014.946818

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

Authors:  John Condeelis; Jeffrey W Pollard
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

2.  Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis.

Authors:  Ole Helm; Janka Held-Feindt; Evelin Grage-Griebenow; Norbert Reiling; Hendrik Ungefroren; Ilka Vogel; Uwe Krüger; Thomas Becker; Michael Ebsen; Christoph Röcken; Dieter Kabelitz; Heiner Schäfer; Susanne Sebens
Journal:  Int J Cancer       Date:  2014-02-05       Impact factor: 7.396

3.  Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity.

Authors:  Lee B Rivera; Gabriele Bergers
Journal:  Cancer Cell       Date:  2013-12-09       Impact factor: 31.743

4.  TGF-β1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells.

Authors:  H Schäfer; B Struck; E-M Feldmann; F Bergmann; E Grage-Griebenow; C Geismann; S Ehlers; P Altevogt; S Sebens
Journal:  Oncogene       Date:  2012-02-20       Impact factor: 9.867

5.  Role of macrophage targeting in the antitumor activity of trabectedin.

Authors:  Giovanni Germano; Roberta Frapolli; Cristina Belgiovine; Achille Anselmo; Samantha Pesce; Manuela Liguori; Eugenio Erba; Sarah Uboldi; Massimo Zucchetti; Fabio Pasqualini; Manuela Nebuloni; Nico van Rooijen; Roberta Mortarini; Luca Beltrame; Sergio Marchini; Ilaria Fuso Nerini; Roberta Sanfilippo; Paolo G Casali; Silvana Pilotti; Carlos M Galmarini; Andrea Anichini; Alberto Mantovani; Maurizio D'Incalci; Paola Allavena
Journal:  Cancer Cell       Date:  2013-02-11       Impact factor: 31.743

Review 6.  Macrophage polarization in tumour progression.

Authors:  Antonio Sica; Paola Larghi; Alessandra Mancino; Luca Rubino; Chiara Porta; Maria Grazia Totaro; Monica Rimoldi; Subhra Kumar Biswas; Paola Allavena; Alberto Mantovani
Journal:  Semin Cancer Biol       Date:  2008-03-26       Impact factor: 15.707

Review 7.  Origin and physiological roles of inflammation.

Authors:  Ruslan Medzhitov
Journal:  Nature       Date:  2008-07-24       Impact factor: 49.962

8.  EMT and dissemination precede pancreatic tumor formation.

Authors:  Andrew D Rhim; Emily T Mirek; Nicole M Aiello; Anirban Maitra; Jennifer M Bailey; Florencia McAllister; Maximilian Reichert; Gregory L Beatty; Anil K Rustgi; Robert H Vonderheide; Steven D Leach; Ben Z Stanger
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

9.  Immune infiltrates as predictive markers of survival in pancreatic cancer patients.

Authors:  Maria Pia Protti; Lucia De Monte
Journal:  Front Physiol       Date:  2013-08-09       Impact factor: 4.566

10.  Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma.

Authors:  Ole Helm; Ruben Mennrich; Domantas Petrick; Lisa Goebel; Sandra Freitag-Wolf; Christian Röder; Holger Kalthoff; Christoph Röcken; Bence Sipos; Dieter Kabelitz; Heiner Schäfer; Hans-Heinrich Oberg; Daniela Wesch; Susanne Sebens
Journal:  PLoS One       Date:  2014-05-05       Impact factor: 3.240
  10 in total
  13 in total

1.  Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape.

Authors:  Brian Hie; Hyunghoon Cho; Benjamin DeMeo; Bryan Bryson; Bonnie Berger
Journal:  Cell Syst       Date:  2019-06-05       Impact factor: 10.304

Review 2.  Renal Macrophages and Dendritic Cells in SLE Nephritis.

Authors:  Naomi I Maria; Anne Davidson
Journal:  Curr Rheumatol Rep       Date:  2017-11-09       Impact factor: 4.592

3.  Tissue Phenomics for prognostic biomarker discovery in low- and intermediate-risk prostate cancer.

Authors:  Nathalie Harder; Maria Athelogou; Harald Hessel; Nicolas Brieu; Mehmet Yigitsoy; Johannes Zimmermann; Martin Baatz; Alexander Buchner; Christian G Stief; Thomas Kirchner; Gerd Binnig; Günter Schmidt; Ralf Huss
Journal:  Sci Rep       Date:  2018-03-13       Impact factor: 4.379

Review 4.  Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice.

Authors:  Sharmilla Devi Jayasingam; Marimuthu Citartan; Thean Hock Thang; Anani Aila Mat Zin; Kai Cheen Ang; Ewe Seng Ch'ng
Journal:  Front Oncol       Date:  2020-01-24       Impact factor: 6.244

Review 5.  Homeostasis, regeneration and tumour formation in the mammalian epidermis.

Authors:  Daria Belokhvostova; Ieva Berzanskyte; Ana-Maria Cujba; Geraldine Jowett; Lucy Marshall; Johanna Prueller; Fiona M Watt
Journal:  Int J Dev Biol       Date:  2018       Impact factor: 2.203

6.  BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

Authors:  Alessandra Rosati; Anna Basile; Raffaella D'Auria; Morena d'Avenia; Margot De Marco; Antonia Falco; Michelina Festa; Luana Guerriero; Vittoria Iorio; Roberto Parente; Maria Pascale; Liberato Marzullo; Renato Franco; Claudio Arra; Antonio Barbieri; Domenica Rea; Giulio Menichini; Michael Hahne; Maarten Bijlsma; Daniela Barcaroli; Gianluca Sala; Fabio Francesco di Mola; Pierluigi di Sebastiano; Jelena Todoric; Laura Antonucci; Vincent Corvest; Anass Jawhari; Matthew A Firpo; David A Tuveson; Mario Capunzo; Michael Karin; Vincenzo De Laurenzi; Maria Caterina Turco
Journal:  Nat Commun       Date:  2015-11-02       Impact factor: 14.919

7.  Distribution pattern of tumor associated macrophages predicts the prognosis of gastric cancer.

Authors:  Jiu-Yang Liu; Chun-Wei Peng; Gui-Fang Yang; Wen-Qing Hu; Xiao-Jun Yang; Chao-Qun Huang; Bin Xiong; Yan Li
Journal:  Oncotarget       Date:  2017-10-06

8.  Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages.

Authors:  Ineta Popēna; Artūrs Ābols; Līga Saulīte; Kārlis Pleiko; Elīna Zandberga; Kaspars Jēkabsons; Edgars Endzeliņš; Alicia Llorente; Aija Linē; Una Riekstiņa
Journal:  Cell Commun Signal       Date:  2018-04-24       Impact factor: 5.712

9.  M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling.

Authors:  Zhaoyun Zong; Jiahuan Zou; Rudi Mao; Chao Ma; Na Li; Jianing Wang; Xiaoyan Wang; Huaiyu Zhou; Lining Zhang; Yongyu Shi
Journal:  Front Immunol       Date:  2019-07-16       Impact factor: 7.561

10.  Macrophage polarization by MSC-derived CXCL12 determines tumor growth.

Authors:  Shabnam Babazadeh; Seyed Mahdi Nassiri; Vahid Siavashi; Mohadeseh Sahlabadi; Mostafa Hajinasrollah; Mohamad Zamani-Ahmadmahmudi
Journal:  Cell Mol Biol Lett       Date:  2021-06-26       Impact factor: 5.787
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.