| Literature DB >> 16439202 |
John Condeelis1, Jeffrey W Pollard.
Abstract
Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.Entities:
Mesh：
Year: 2006 PMID： 16439202 DOI： 10.1016/j.cell.2006.01.007
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582