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Literature DB >> 25607684

Elongator, a conserved complex required for wobble uridine modifications in eukaryotes.

Tony Karlsborn¹, Hasan Tükenmez, A K M Firoj Mahmud, Fu Xu, Hao Xu, Anders S Byström.

Abstract

Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the cellular processes that have been linked to the Elongator complex and discuss its role in tRNA modification and regulation of translation. We also describe additional gene products essential for formation of ncm(5) and mcm(5) side chains at U34 and their influence on Elongator activity.

Entities: Chemical Species

Keywords: KTI genes; Kluveromyces lactis γ-toxin; SAP genes; SIT4; elongator complex; tRNA wobble uridine modifications,; translation

Mesh：

Substances：

Year: 2014 PMID： 25607684 PMCID： PMC4615193 DOI： 10.4161/15476286.2014.992276

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

105 in total

1. Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.

Authors: Anders Esberg; Bo Huang; Marcus J O Johansson; Anders S Byström
Journal: Mol Cell Date: 2006-10-06 Impact factor: 17.970

2. Human Elongator facilitates RNA polymerase II transcription through chromatin.

Authors: Jae-Hyun Kim; William S Lane; Danny Reinberg
Journal: Proc Natl Acad Sci U S A Date: 2002-01-29 Impact factor: 11.205

3. Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A.

Authors: Philippe C Durant; Ashok C Bajji; Mallikarjun Sundaram; Raju K Kumar; Darrell R Davis
Journal: Biochemistry Date: 2005-06-07 Impact factor: 3.162

4. An early step in wobble uridine tRNA modification requires the Elongator complex.

Authors: Bo Huang; Marcus J O Johansson; Anders S Byström
Journal: RNA Date: 2005-04 Impact factor: 4.942

5. Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.

Authors: Yumi Nakai; Masato Nakai; Hideyuki Hayashi
Journal: J Biol Chem Date: 2008-07-29 Impact factor: 5.157

6. Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.

Authors: Yei-Tsung Chen; Matthew M Hims; Ranjit S Shetty; James Mull; Lijuan Liu; Maire Leyne; Susan A Slaugenhaupt
Journal: Mol Cell Biol Date: 2008-11-17 Impact factor: 4.272

7. Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin.

Authors: A R Butler; J H White; Y Folawiyo; A Edlin; D Gardiner; M J Stark
Journal: Mol Cell Biol Date: 1994-09 Impact factor: 4.272

8. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.

Authors: Claire L Simpson; Robin Lemmens; Katarzyna Miskiewicz; Wendy J Broom; Valerie K Hansen; Paul W J van Vught; John E Landers; Peter Sapp; Ludo Van Den Bosch; Joanne Knight; Benjamin M Neale; Martin R Turner; Jan H Veldink; Roel A Ophoff; Vineeta B Tripathi; Ana Beleza; Meera N Shah; Petroula Proitsi; Annelies Van Hoecke; Peter Carmeliet; H Robert Horvitz; P Nigel Leigh; Christopher E Shaw; Leonard H van den Berg; Pak C Sham; John F Powell; Patrik Verstreken; Robert H Brown; Wim Robberecht; Ammar Al-Chalabi
Journal: Hum Mol Genet Date: 2008-11-07 Impact factor: 6.150

9. Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.

Authors: Akiko Noma; Yuriko Sakaguchi; Tsutomu Suzuki
Journal: Nucleic Acids Res Date: 2009-01-16 Impact factor: 16.971

10. Loss of a conserved tRNA anticodon modification perturbs cellular signaling.

Authors: Boris Zinshteyn; Wendy V Gilbert
Journal: PLoS Genet Date: 2013-08-01 Impact factor: 5.917

52 in total

1. Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis.

Authors: Min Dong; Yugang Zhang; Hening Lin
Journal: Biochemistry Date: 2018-05-10 Impact factor: 3.162

Review 2. Translational Control under Stress: Reshaping the Translatome.

Authors: Vivek M Advani; Pavel Ivanov
Journal: Bioessays Date: 2019-05 Impact factor: 4.345

3. Loss of ncm⁵ and mcm⁵ wobble uridine side chains results in an altered metabolic profile.

Authors: Hasan Tükenmez; Tony Karlsborn; A K M Firoj Mahmud; Anders S Byström
Journal: Metabolomics Date: 2016-09-27 Impact factor: 4.290

Review 4. tRNA wobble modifications and protein homeostasis.

Authors: Namit Ranjan; Marina V Rodnina
Journal: Translation (Austin) Date: 2016-01-28

5. Elongator controls cortical interneuron migration by regulating actomyosin dynamics.

Authors: Sylvia Tielens; Sandra Huysseune; Juliette D Godin; Alain Chariot; Brigitte Malgrange; Laurent Nguyen
Journal: Cell Res Date: 2016-09-27 Impact factor: 25.617

Review 6. Protein folding and tRNA biology.

Authors: Mónica Marín; Tamara Fernández-Calero; Ricardo Ehrlich
Journal: Biophys Rev Date: 2017-09-24