Kari Anne Sveen1, Knut Dahl-Jørgensen2, Knut Haakon Stensaeth3, Kristin Angel4, Ingebjørg Seljeflot5, David R Sell6, Vincent M Monnier6, Kristian F Hanssen7. 1. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, Norway. Electronic address: k.a.sveen@medisin.uio.no. 2. Department of Pediatrics, Oslo University Hospital, Ullevaal, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, Norway. 3. Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. 4. Department of Cardiology, Oslo University Hospital, Oslo, Norway. 5. Department of Cardiology, Oslo University Hospital, Oslo, Norway; Center for Clinical Heart Research, Oslo University hospital, Ullevaal, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, Norway. 6. Departments of Pathology and Biochemistry Case Western Reserve University, Cleveland, OH, USA. 7. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, Norway.
Abstract
AIMS: To study intima media thickness (cIMT) and arterial stiffness in type 1 diabetes of long duration, and their associations with the collagen cross-linker glucosepane and inflammatory and oxidative markers. METHODS:Twenty-seven individuals with type 1 diabetes mellitus of 40 years duration from the Oslo Study cohort and24 age-matched controls were included. cIMT measurements of the carotid artery were performed longitudinally. Pulse wave velocity (PWV), augmentation index (AIx) and augmentation pressure (AP) were assessed cross-sectionally. Glucosepane and the oxidative product methionine sulfoxide (MetSO) were determined in skin collagen by liquid chromatography-mass spectrometry. Circulating inflammatory markers were determined by ELISAs. RESULTS: The diabetes patients had significantly increased cIMT and arterial stiffness compared to controls. Significant correlations were noted for skin glucosepane with cIMT (r=0.41) and PWV (r=0.44). Skin MetSO and monocyte chemoattractant protein-1 (MCP-1) correlated significantly with AIx and AP. After correcting for age and mean arterial pressure in multiple linear regression analysis, MetSO and MCP-1 were both independently associated with AIx and AP. CONCLUSIONS: These results suggest more premature atherosclerosis and arterial pathology in individuals with diabetes compared to age-matched controls. They also suggest an association between the arterial pathology and markers of collagen crosslinking, oxidative damage and inflammation in type 1 diabetes patients of forty years disease duration.
RCT Entities:
AIMS: To study intima media thickness (cIMT) and arterial stiffness in type 1 diabetes of long duration, and their associations with the collagen cross-linker glucosepane and inflammatory and oxidative markers. METHODS: Twenty-seven individuals with type 1 diabetes mellitus of 40 years duration from the Oslo Study cohort and 24 age-matched controls were included. cIMT measurements of the carotid artery were performed longitudinally. Pulse wave velocity (PWV), augmentation index (AIx) and augmentation pressure (AP) were assessed cross-sectionally. Glucosepane and the oxidative product methionine sulfoxide (MetSO) were determined in skin collagen by liquid chromatography-mass spectrometry. Circulating inflammatory markers were determined by ELISAs. RESULTS: The diabetespatients had significantly increased cIMT and arterial stiffness compared to controls. Significant correlations were noted for skin glucosepane with cIMT (r=0.41) and PWV (r=0.44). Skin MetSO and monocyte chemoattractant protein-1 (MCP-1) correlated significantly with AIx and AP. After correcting for age and mean arterial pressure in multiple linear regression analysis, MetSO and MCP-1 were both independently associated with AIx and AP. CONCLUSIONS: These results suggest more premature atherosclerosis and arterial pathology in individuals with diabetes compared to age-matched controls. They also suggest an association between the arterial pathology and markers of collagen crosslinking, oxidative damage and inflammation in type 1 diabetespatients of forty years disease duration.
Authors: Kristine B Holte; Mona Svanteson; Kristian F Hanssen; Kari Anne Sveen; Ingebjørg Seljeflot; Svein Solheim; David R Sell; Vincent M Monnier; Tore Julsrud Berg Journal: PLoS One Date: 2020-05-13 Impact factor: 3.240
Authors: Vincent M Monnier; Wanjie Sun; Xiaoyu Gao; David R Sell; Patricia A Cleary; John M Lachin; Saul Genuth Journal: Cardiovasc Diabetol Date: 2015-09-05 Impact factor: 9.951