BACKGROUND: The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. OBJECTIVES: This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. METHODS:Patients with ICM who receivedMSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI. RESULTS: The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age. CONCLUSIONS:MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy.
RCT Entities:
BACKGROUND: The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. OBJECTIVES: This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. METHODS:Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI. RESULTS: The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age. CONCLUSIONS:MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy.
Authors: David M Leistner; Ulrich Fischer-Rasokat; Jörg Honold; Florian H Seeger; Volker Schächinger; Ralf Lehmann; Hans Martin; Iris Burck; Carmen Urbich; Stefanie Dimmeler; Andreas M Zeiher; Birgit Assmus Journal: Clin Res Cardiol Date: 2011-06-03 Impact factor: 5.460
Authors: Luis M de la Fuente; Simon H Stertzer; Julio Argentieri; Eduardo Peñaloza; Jorge Miano; Benjamin Koziner; Cristian Bilos; Peter A Altman Journal: Am Heart J Date: 2007-07 Impact factor: 4.749
Authors: B Middel; J Bouma; M de Jongste; E van Sonderen; M G Niemeijer; H Crijns; W van den Heuvel Journal: Clin Rehabil Date: 2001-10 Impact factor: 3.477
Authors: Volker Schächinger; Sandra Erbs; Albrecht Elsässer; Werner Haberbosch; Rainer Hambrecht; Hans Hölschermann; Jiangtao Yu; Roberto Corti; Detlef G Mathey; Christian W Hamm; Tim Süselbeck; Birgit Assmus; Torsten Tonn; Stefanie Dimmeler; Andreas M Zeiher Journal: N Engl J Med Date: 2006-09-21 Impact factor: 91.245
Authors: E Wu; J T Ortiz; P Tejedor; D C Lee; C Bucciarelli-Ducci; P Kansal; J C Carr; T A Holly; D Lloyd-Jones; F J Klocke; R O Bonow Journal: Heart Date: 2007-12-10 Impact factor: 5.994
Authors: Melissa A Baxter; Robert F Wynn; Simon N Jowitt; J Ed Wraith; Leslie J Fairbairn; Ilaria Bellantuono Journal: Stem Cells Date: 2004 Impact factor: 6.277
Authors: Alan W Heldman; Darcy L DiFede; Joel E Fishman; Juan P Zambrano; Barry H Trachtenberg; Vasileios Karantalis; Muzammil Mushtaq; Adam R Williams; Viky Y Suncion; Ian K McNiece; Eduard Ghersin; Victor Soto; Gustavo Lopera; Roberto Miki; Howard Willens; Robert Hendel; Raul Mitrani; Pradip Pattany; Gary Feigenbaum; Behzad Oskouei; John Byrnes; Maureen H Lowery; Julio Sierra; Mariesty V Pujol; Cindy Delgado; Phillip J Gonzalez; Jose E Rodriguez; Luiza Lima Bagno; Didier Rouy; Peter Altman; Cheryl Wong Po Foo; Jose da Silva; Erica Anderson; Richard Schwarz; Adam Mendizabal; Joshua M Hare Journal: JAMA Date: 2014-01-01 Impact factor: 56.272
Authors: Natesh Parashurama; Byeong-Cheol Ahn; Keren Ziv; Ken Ito; Ramasamy Paulmurugan; Jürgen K Willmann; Jaehoon Chung; Fumiaki Ikeno; Julia C Swanson; Denis R Merk; Jennifer K Lyons; David Yerushalmi; Tomohiko Teramoto; Hisanori Kosuge; Catherine N Dao; Pritha Ray; Manishkumar Patel; Ya-Fang Chang; Morteza Mahmoudi; Jeff Eric Cohen; Andrew Brooks Goldstone; Frezghi Habte; Srabani Bhaumik; Shahriar Yaghoubi; Robert C Robbins; Rajesh Dash; Phillip C Yang; Todd J Brinton; Paul G Yock; Michael V McConnell; Sanjiv S Gambhir Journal: Radiology Date: 2016-06-16 Impact factor: 11.105
Authors: Victoria Florea; Angela C Rieger; Makoto Natsumeda; Bryon A Tompkins; Monisha N Banerjee; Ivonne H Schulman; Courtney Premer; Aisha Khan; Krystalenia Valasaki; Bettina Heidecker; Alejandro Mantero; Wayne Balkan; Raul D Mitrani; Joshua M Hare Journal: Cardiovasc Res Date: 2020-11-01 Impact factor: 10.787