Literature DB >> 2559264

Treatment of small cell lung cancer by eight weeks chemotherapy.

S M Crawford1, D Parker, M G Glaser, B M Southcott, R H Begent, G J Rustin, E S Newlands, A J Ward, K D Bagshawe.   

Abstract

Eighty-two patients with small cell lung cancer (SCLC), 32 with limited disease, were treated with alternating chemotherapy. Eight courses were administered at weekly intervals, and responding patients received radiotherapy to sites of bulk disease. Overall response rate was 76.8%. Overall median survival was 265 days, 408 days in patients with limited disease. The median symptom free period after chemotherapy was completed was 123 days. These results are comparable with those in reports of chemotherapy of longer duration and warrant the further investigation of short duration treatment in this disease.

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Year:  1989        PMID： 2559264     DOI： 10.1007/BF02985162

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  22 in total

1.  The impact of chemotherapy on small cell carcinoma of the bronchus.

Authors:  J F Smyth; S M Fowlie; A Gregor; G K Crompton; A Busuttil; R C Leonard; I W Grant
Journal:  Q J Med       Date:  1986-10

2.  A randomized comparison of high-dose versus conventional-dose cyclophosphamide, doxorubicin, and vincristine for extensive-stage small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group.

Authors:  D H Johnson; L H Einhorn; R Birch; R Vollmer; C Perez; S Krauss; G Omura; F A Greco
Journal:  J Clin Oncol       Date:  1987-11       Impact factor: 44.544

3.  Small-cell lung carcinoma: survival after combination chemotherapy, radiotherapy or symptomatic treatment.

Authors:  M L Slevin; V J Harvey; B A Ponder; S Messina; R C Stuart-Harris; T A Lister; J S Malpas; P F Wrigley
Journal:  Br J Dis Chest       Date:  1983-10

4.  Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial.

Authors:  R L Souhami; D M Geddes; S G Spiro; P G Harper; J S Tobias; B S Mantell; F Fearon; I Bradbury
Journal:  Br Med J (Clin Res Ed)       Date:  1984-06-02

5.  Continuous versus alternating combination chemotherapy for advanced small cell carcinoma of the lung.

Authors:  K Osterlind; S Sörenson; H H Hansen; P Dombernowsky; F R Hirsch; M Hansen; M Rørth
Journal:  Cancer Res       Date:  1983-12       Impact factor: 12.701

6.  High-dose cyclophosphamide with autologous marrow transplantation for small cell carcinoma of the bronchus.

Authors:  R L Souhami; P G Harper; D Linch; C Trask; A H Goldstone; J S Tobias; S G Spiro; D M Geddes; J D Richards
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

7.  Etoposide and cisplatin salvage chemotherapy for small cell lung cancer.

Authors:  J A Lopez; J Mann; R T Grapski; E Nassif; P Vannicola; J G Krikorian; H Finkel
Journal:  Cancer Treat Rep       Date:  1985-04

8.  Chemotherapy of small-cell carcinoma of lung: a randomized comparison of alternating and sequential combination chemotherapy programs.

Authors:  J R Daniels; L Y Chak; B I Sikic; P Lockbaum; M Kohler; S K Carter; R Reynolds; R Bohnen; D Gandara; J Yu
Journal:  J Clin Oncol       Date:  1984-11       Impact factor: 44.544

9.  A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

Authors:  J H Goldie; A J Coldman
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

10.  A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent.

Authors:  K B Carroll; H Moussalli; D Brown; N Thatcher
Journal:  Br J Dis Chest       Date:  1983-04
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