Salim Uz-Zaman1, Joyashree Banerjee2, Anilbaran Singhamahapatra3, Pranab Kumar Dey4, Anindya Roy2, Kaushik Roy5, Kakali Roy Basu6. 1. Assistant Professor, Department of Physiology, Murshidabad Medical College , Berhampore, India . 2. Assistant Professor, Department of Physiology, RGKar Medical College , Kolkata, India . 3. Professor and Head, Department of Physiology, RGKar Medical College , Kolkata, India . 4. Assistant Professor, Department of Paediatrics Midnapur Medical College , Midnapur, India . 5. Junior Resident, Department of Physiology, RGKar Medical College , Kolkata, India . 6. Professor and Head, Department of Physiology, Malda Medical College , Malda, India .
Abstract
INTRODUCTION: There are so many complications involving eyes, kidneys, lungs and nerves associated with diabetes. But, pulmonary complications are poorly characterized among eastern Indian diabetic populations. AIMS AND OBJECTIVES: To assess pulmonary function in patients with type 2 diabetes mellitus. To find out correlation of the pulmonary functions test variables with Glycemic control. MATERIALS AND METHODS: Total of 60 type 2 diabetes patient of age between 35-55 y and same number of age and sex matched apparently healthy control individual were included in the present study. All subjects were evaluated for PFT by flow sensitive spirometer (RMS HELIOS-401), the spirometric parameters were measured as a percentage of predicted and DLCO (by single breath technique). HBA1c of all cases were measured and they were grouped according to HBA1c level (Group-a =>7%, Group-b =6%-7%, Group-c =<6%). RESULTS: Significant differences in the spirometric parameters (FVC, FEV1/FVC) and diffusion capacity (DLCO% and DL/VA%) existed between cases and controls. There was a significant decrease in FVC, DLCO and DL/VA and significant increase in FEV1/FVC in that groups having HBA1c level >7% than the other groups. FEV1, FVC, DLCO, and DL/VA were negatively correlated with HbA1c where as FEV1/FVC has positive association with HbA1c. CONCLUSION: Significant deterioration of lung function and diffusing capacity was observed in type 2 diabetes patients with poor glycemic control.
INTRODUCTION: There are so many complications involving eyes, kidneys, lungs and nerves associated with diabetes. But, pulmonary complications are poorly characterized among eastern Indian diabetic populations. AIMS AND OBJECTIVES: To assess pulmonary function in patients with type 2 diabetes mellitus. To find out correlation of the pulmonary functions test variables with Glycemic control. MATERIALS AND METHODS: Total of 60 type 2 diabetespatient of age between 35-55 y and same number of age and sex matched apparently healthy control individual were included in the present study. All subjects were evaluated for PFT by flow sensitive spirometer (RMS HELIOS-401), the spirometric parameters were measured as a percentage of predicted and DLCO (by single breath technique). HBA1c of all cases were measured and they were grouped according to HBA1c level (Group-a =>7%, Group-b =6%-7%, Group-c =<6%). RESULTS: Significant differences in the spirometric parameters (FVC, FEV1/FVC) and diffusion capacity (DLCO% and DL/VA%) existed between cases and controls. There was a significant decrease in FVC, DLCO and DL/VA and significant increase in FEV1/FVC in that groups having HBA1c level >7% than the other groups. FEV1, FVC, DLCO, and DL/VA were negatively correlated with HbA1c where as FEV1/FVC has positive association with HbA1c. CONCLUSION: Significant deterioration of lung function and diffusing capacity was observed in type 2 diabetespatients with poor glycemic control.
Entities:
Keywords:
Glycemic control; Pulmonary function test; Type-2 diabetes mellitus
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