OBJECTIVE: To examine prospectively the relationship between diabetes, glycemic control, and spirometric measures. RESEARCH DESIGN AND METHODS: From a community-based cohort, 495 Europid (i.e., of European descent) patients with type 2 diabetes who had no history of pulmonary disease underwent baseline spirometry between 1993 and 1994. A subset of 125 patients was restudied a mean of 7.0 years later. The main outcome measures included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), vital capacity (VC), and peak expiratory flow (PEF) corrected for body temperature, air pressure, and water saturation and were expressed either in absolute terms or as percentage-predicted value for age, sex, and height. RESULTS: Mean percentage-predicted values of each spirometric measure were decreased >10% in the whole cohort at baseline and absolute measures continued to decline at an annual rate of 68, 71, and 84 ml/year and 17 l/min for FVC, FEV1, VC, and PEF, respectively, in the 125 prospectively studied patients. Declining lung function measures were consistently predicted by poor glycemic control in the form of a higher updated mean HbA1c, follow-up HbA1c, or follow-up fasting plasma glucose. In a Cox proportional hazards model, decreased FEV1 percentage-predicted value was an independent predictor of all-cause mortality. CONCLUSIONS: Reduced lung volumes and airflow limitation are likely to be chronic complications of type 2 diabetes, the severity of which relates to glycemic exposure. Airflow limitation is a predictor of death in type 2 diabetes after adjusting for other recognized risk factors.
OBJECTIVE: To examine prospectively the relationship between diabetes, glycemic control, and spirometric measures. RESEARCH DESIGN AND METHODS: From a community-based cohort, 495 Europid (i.e., of European descent) patients with type 2 diabetes who had no history of pulmonary disease underwent baseline spirometry between 1993 and 1994. A subset of 125 patients was restudied a mean of 7.0 years later. The main outcome measures included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), vital capacity (VC), and peak expiratory flow (PEF) corrected for body temperature, air pressure, and water saturation and were expressed either in absolute terms or as percentage-predicted value for age, sex, and height. RESULTS: Mean percentage-predicted values of each spirometric measure were decreased >10% in the whole cohort at baseline and absolute measures continued to decline at an annual rate of 68, 71, and 84 ml/year and 17 l/min for FVC, FEV1, VC, and PEF, respectively, in the 125 prospectively studied patients. Declining lung function measures were consistently predicted by poor glycemic control in the form of a higher updated mean HbA1c, follow-up HbA1c, or follow-up fasting plasma glucose. In a Cox proportional hazards model, decreased FEV1 percentage-predicted value was an independent predictor of all-cause mortality. CONCLUSIONS: Reduced lung volumes and airflow limitation are likely to be chronic complications of type 2 diabetes, the severity of which relates to glycemic exposure. Airflow limitation is a predictor of death in type 2 diabetes after adjusting for other recognized risk factors.
Authors: F Gómez Real; C Svanes; E H Björnsson; K A Franklin; K Franklin; D Gislason; T Gislason; A Gulsvik; C Janson; R Jögi; T Kiserud; D Norbäck; L Nyström; K Torén; T Wentzel-Larsen; E Omenaas Journal: Thorax Date: 2005-10-21 Impact factor: 9.139
Authors: Lesley M Butler; Woon-Puay Koh; Hin-Peng Lee; Marilyn Tseng; Mimi C Yu; Stephanie J London Journal: Am J Respir Crit Care Med Date: 2005-10-20 Impact factor: 21.405
Authors: Rodolfo J Dennis; Dario Maldonado; Maria X Rojas; Pablo Aschner; Martin Rondón; Laura Charry; Alejandro Casas Journal: BMC Pulm Med Date: 2010-07-26 Impact factor: 3.317
Authors: Samantha F Ehrlich; Charles P Quesenberry; Stephen K Van Den Eeden; Jun Shan; Assiamira Ferrara Journal: Diabetes Care Date: 2009-10-06 Impact factor: 19.112