Literature DB >> 25582897

Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp.

Arihiro Iwasaki1, Osamu Ohno, Shinpei Sumimoto, Hidetoshi Ogawa, Kim Anh Nguyen, Kiyotake Suenaga.   

Abstract

An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

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Year:  2015        PMID： 25582897     DOI： 10.1021/ol5036722

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.

Authors:  Shaden A M Khalifa; Eslam S Shedid; Essa M Saied; Amir Reza Jassbi; Fatemeh H Jamebozorgi; Mostafa E Rateb; Ming Du; Mohamed M Abdel-Daim; Guo-Yin Kai; Montaser A M Al-Hammady; Jianbo Xiao; Zhiming Guo; Hesham R El-Seedi
Journal:  Mar Drugs       Date:  2021-04-24       Impact factor: 5.118

Review 2.  Natural Proline-Rich Cyclopolypeptides from Marine Organisms: Chemistry, Synthetic Methodologies and Biological Status.

Authors:  Wan-Yin Fang; Rajiv Dahiya; Hua-Li Qin; Rita Mourya; Sandeep Maharaj
Journal:  Mar Drugs       Date:  2016-10-26       Impact factor: 5.118

Review 3.  Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review.

Authors:  Sayed Asmat Ali Shah; Najeeb Akhter; Bibi Nazia Auckloo; Ishrat Khan; Yanbin Lu; Kuiwu Wang; Bin Wu; Yue-Wei Guo
Journal:  Mar Drugs       Date:  2017-11-10       Impact factor: 5.118

Review 4.  New Peptides Isolated from Marine Cyanobacteria, an Overview over the Past Decade.

Authors:  Yue Mi; Jinrong Zhang; Shan He; Xiaojun Yan
Journal:  Mar Drugs       Date:  2017-05-05       Impact factor: 5.118

5.  Total Synthesis of Desmethyl Jahanyne and Its Lipo-Tetrapeptide Conjugates Derived from Parent Skeleton as BCL-2-Mediated Apoptosis-Inducing Agents.

Authors:  Shivakrishna Kallepu; Minnapuram Kavitha; Ragini Yeeravalli; Kanakaraju Manupati; Surender Singh Jadav; Amitava Das; Prathama S Mainkar; Srivari Chandrasekhar
Journal:  ACS Omega       Date:  2018-01-04

6.  Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii.

Authors:  Christopher A Leber; C Benjamin Naman; Lena Keller; Jehad Almaliti; Eduardo J E Caro-Diaz; Evgenia Glukhov; Valsamma Joseph; T P Sajeevan; Andres Joshua Reyes; Jason S Biggs; Te Li; Ye Yuan; Shan He; Xiaojun Yan; William H Gerwick
Journal:  Mar Drugs       Date:  2020-10-14       Impact factor: 5.118

7.  Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers.

Authors:  Baijun Ye; Jianmiao Gong; Qiuying Li; Shiqi Bao; Xuemei Zhang; Jing Chen; Qing Meng; Bolin Chen; Peng Jiang; Liang Wang; Yue Chen
Journal:  Mar Drugs       Date:  2020-03-23       Impact factor: 5.118
  7 in total

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