Shaden A M Khalifa1, Eslam S Shedid2, Essa M Saied3,4, Amir Reza Jassbi5, Fatemeh H Jamebozorgi5, Mostafa E Rateb6, Ming Du7, Mohamed M Abdel-Daim8, Guo-Yin Kai9, Montaser A M Al-Hammady10, Jianbo Xiao11, Zhiming Guo12, Hesham R El-Seedi2,13,14. 1. Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden. 2. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt. 3. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt. 4. Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany. 5. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-53734, Iran. 6. School of Computing, Engineering & Physical Sciences, University of the West of Scotland, High Street, Paisley PA1 2BE, UK. 7. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China. 8. Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. 9. Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311402, China. 10. National Institute of Oceanography & Fisheries, NIOF, Cairo 11516, Egypt. 11. Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China. 12. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. 13. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China. 14. Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, P.O. Box 574, SE-751 23 Uppsala, Sweden.
Abstract
Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.
Cyanobacteria are photo<n class="Chemical">spanpan> class="Gene">synpan>>thetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, <spn>an class="Chemical">and they are also considered an abundant source of bioactive compounds/drugs, such as <span class="Chemical">dolastatin, cryptophycin 1, curacintoyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicityand antiviral activity against HCMV, HSV-1, HHV-6andHIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.
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