A nitrosopurine ene reaction easily assembles the asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 μM IC50) and supersede the metabolites as useful leads for biological discovery.
A nitrosopurine ene reaction easily assembles the n class="Chemical">asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 μM IC50) and supersede the metabolites as useful leads for biological discovery.
Authors: Adriana A Pimentel; Pimali Felibertt; Felipe Sojo; Laura Colman; Adriana Mayora; May Li Silva; Hector Rojas; Reinaldo Dipolo; Alírica I Suarez; Reinaldo S Compagnone; Francisco Arvelo; Ivan Galindo-Castro; Juan B De Sanctis; Perla Chirino; Gustavo Benaim Journal: Cancer Chemother Pharmacol Date: 2011-05-21 Impact factor: 3.333
Authors: R Fathi-Afshar; T M Allen; C A Krueger; D A Cook; A S Clanachan; R Vriend; H P Baer; C E Cass Journal: Can J Physiol Pharmacol Date: 1989-04 Impact factor: 2.273
Authors: Anders Vik; Erik Hedner; Colin Charnock; Linda W Tangen; Ørjan Samuelsen; Rolf Larsson; Lars Bohlin; Lise-Lotte Gundersen Journal: Bioorg Med Chem Date: 2007-04-02 Impact factor: 3.641