| Literature DB >> 17442577 |
Anders Vik1, Erik Hedner, Colin Charnock, Linda W Tangen, Ørjan Samuelsen, Rolf Larsson, Lars Bohlin, Lise-Lotte Gundersen.
Abstract
Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 microM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.Entities:
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Year: 2007 PMID： 17442577 DOI： 10.1016/j.bmc.2007.03.086
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641