Literature DB >> 25579174

5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer.

Leonie I Kroeze1, Bert A van der Reijden2, Joop H Jansen3.   

Abstract

The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since 2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the conversion of 5-methylcytosine (5mC) into 5hmC. This conversion appears to be an intermediate step in the active DNA demethylation pathway. Factors that regulate DNA hydroxymethylation are frequently affected in cancer, leading to deregulated 5hmC levels. In this review, we will discuss the regulation of DNA hydroxymethylation, defects in this pathway in cancer, and novel therapies that may correct deregulated (hydroxy)methylation of DNA.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  5-Hydroxymethylcytosine; Cancer; DNA methylation; IDH; TET

Mesh：

Substances：

Year:  2015        PMID： 25579174     DOI： 10.1016/j.bbcan.2015.01.001

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  41 in total

1.  Re-expression of Selected Epigenetically Silenced Candidate Tumor Suppressor Genes in Cervical Cancer by TET2-directed Demethylation.

Authors:  Christian Huisman; Monique G P van der Wijst; Matthijs Schokker; Pilar Blancafort; Martijn M Terpstra; Klaas Kok; Ate G J van der Zee; Ed Schuuring; G Bea A Wisman; Marianne G Rots
Journal:  Mol Ther       Date:  2015-12-21       Impact factor: 11.454

2.  Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells.

Authors:  Christian Grosser; Nicholas Wagner; Katrin Grothaus; Bernhard Horsthemke
Journal:  Epigenetics       Date:  2015-07-17       Impact factor: 4.528

Review 3.  lnflammation-induced epigenetic switches in cancer.

Authors:  Matjaz Rokavec; Meryem Gülfem Öner; Heiko Hermeking
Journal:  Cell Mol Life Sci       Date:  2015-09-22       Impact factor: 9.261

Review 4.  The Role of DNA Methylation in Lens Development and Cataract Formation.

Authors:  Yong Wang; Huaijin Guan
Journal:  Cell Mol Neurobiol       Date:  2016-11-18       Impact factor: 5.046

Review 5.  Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.

Authors:  Yunhua Peng; Peipei Gao; Le Shi; Lei Chen; Jiankang Liu; Jiangang Long
Journal:  Antioxid Redox Signal       Date:  2020-03-16       Impact factor: 8.401

Review 6.  A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro.

Authors:  Craig L Parfett; Daniel Desaulniers
Journal:  Int J Mol Sci       Date:  2017-06-01       Impact factor: 5.923

Review 7.  Nutritional Epigenetics in Cancer.

Authors:  Maria J Barrero; Paloma Cejas; Henry W Long; Ana Ramirez de Molina
Journal:  Adv Nutr       Date:  2022-10-02       Impact factor: 11.567

8.  Aberrant hydroxymethylation of ANGPTL4 is associated with selective intrauterine growth restriction in monochorionic twin pregnancies.

Authors:  Yi Zhang; Dezhong Zheng; Qun Fang; Mei Zhong
Journal:  Epigenetics       Date:  2020-03-05       Impact factor: 4.528

Review 9.  The epigenetic role of vitamin C in health and disease.

Authors:  Vladimir Camarena; Gaofeng Wang
Journal:  Cell Mol Life Sci       Date:  2016-02-04       Impact factor: 9.261

10.  Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma.

Authors:  Bence Sipos; Andreas K Nussler; Sahar Olsadat Sajadian; Sabrina Ehnert; Haghighat Vakilian; Eirini Koutsouraki; Georg Damm; Daniel Seehofer; Wolfgang Thasler; Steven Dooley; Hossein Baharvand
Journal:  Clin Epigenetics       Date:  2015-09-11       Impact factor: 6.551
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