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Literature DB >> 35421212

Nutritional Epigenetics in Cancer.

Maria J Barrero^1,2, Paloma Cejas^3,4,5, Henry W Long^3,4, Ana Ramirez de Molina¹.

Abstract

Alterations in the epigenome are well known to affect cancer development and progression. Epigenetics is highly influenced by the environment, including diet, which is a source of metabolic substrates that influence the synthesis of cofactors or substrates for chromatin and RNA modifying enzymes. In addition, plants are a common source of bioactives that can directly modify the activity of these enzymes. Here, we review and discuss the impact of diet on epigenetic mechanisms, including chromatin and RNA regulation, and its potential implications for cancer prevention and treatment.

Entities: Chemical

Keywords: DNA methylation; RNA modifications; bioactives; enhancer; histone modifications; metabolism; obesity

Mesh：

Substances：
Chromatin
Histones
RNA

Year: 2022 PMID： 35421212 PMCID： PMC9526851 DOI： 10.1093/advances/nmac039

Source DB: PubMed Journal: Adv Nutr ISSN： 2161-8313 Impact factor: 11.567

Keyword Cloud
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Nutritional Epigenetics in Cancer.

1. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.

2. Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.

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4. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

5. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.

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